2023-10-07T06:46:03+03:00[Europe/Moscow] en true <p>c</p>, <p>a</p>, <p>b</p>, <p>reinforcement </p>, <p>DA, 5HT, glutamate, NE, endogenous opioids, GABA</p>, <p>c</p>, <p>b</p>, <p>a</p>, <p>reduce cravings/withdrawal symptoms, inhibit reinforcing effects </p>, <p>NRT, varenicline, buproprion </p>, <p>clonidine, nortriptyline </p>, <p>same dose of nicotine; increase time</p>, <p>spike </p>, <p>dip </p>, <p>d</p>, <p>b</p>, <p>c</p>, <p>a</p>, <p>VTA; nucleus accumbens </p>, <p>voltage-gated calcium channels </p>, <p>a4B2</p>, <p>potency; binding affinity </p>, <p>partial agonist of a4b2 receptor; prevents nicotine from binding; reduces craving/withdrawal; decreases reward from relapse</p>, <p>f; can increase nausea</p>, <p>NDRI; unicyclic </p>, <p> increases dopaminergic/noradrenergic signaling, mimics nicotines effects; non-competitive antagonist- diminishes reinforcement of nicotine </p>, <p>d</p>, <p>agonist of presynaptic a2 receptors</p>, <p>5-HT &amp; NE reuptake inhibition </p>, <p>b,c </p>, <p>b,c </p>, <p>relief of withdrawal symptoms without spike; desensitizes nAChR- reduced effect of nicotine from cigs </p>, <p>c</p>, <p>b</p>, <p>a</p>, <p>c,d </p> flashcards
Pharmacology of smoking Cessation

Pharmacology of smoking Cessation

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  • c

    Decreased effect with repeating doses; pharmacological adaptation.

    a) substance use disorder

    b) physical dependence

    c) tolerance

  • a

    Engages in compulsive repetition of the experience (drug-seeking).

    a) substance use disorder

    b) physical dependence

    c) tolerance

  • b

    Adaptive responses are now unopposed.

    a) substance use disorder

    b) physical dependence

    c) tolerance

  • reinforcement

    -neuronal activation in reward areas with compulsive repetition of use

  • DA, 5HT, glutamate, NE, endogenous opioids, GABA

    Which NTs are involved in reinforcement? (6)

  • c

    Creating a dislike of addicted drugs; through consequences or punishment

    a) neurotransmitter manipulation

    b) pharmacological substitution

    c) aversive conditioning

  • b

    Substituting one substance that stimulates the brain reward pathway with

    another less addictive/less harmful.

    a) neurotransmitter manipulation

    b) pharmacological substitution

    c) aversive conditioning

  • a

    Manipulating NT in the reward pathway to modify cravings/withdrawal symptoms.

    a) neurotransmitter manipulation

    b) pharmacological substitution

    c) aversive conditioning

  • reduce cravings/withdrawal symptoms, inhibit reinforcing effects

    What are the goals of smoking cessation pharmacotherapy? (2)

  • NRT, varenicline, buproprion

    What are the first-line therapies for smoking cessation? (3)

  • clonidine, nortriptyline

    What are the second-line therapies? (2)

  • same dose of nicotine; increase time

    The patch provides __________ but with an __________ release.

  • spike

    Reinforcement =

  • dip

    Craving =

  • d

    Rewarding stimulus induces dopamine release from the ______.

    a) prefrontal cortex

    b) nucleus accumbens

    c) amygdala

    d) Ventral tegmental area

  • b

    Responsible for regulating survival drives.

    a) prefrontal cortex

    b) nucleus accumbens

    c) amygdala

    d) Ventral tegmental area

  • c

    Retains memory of pleasure.

    a) prefrontal cortex

    b) nucleus accumbens

    c) amygdala

    d) Ventral tegmental area

  • a

    Part of the frontal lobe involved in many cognitive functions.

    a) prefrontal cortex

    b) nucleus accumbens

    c) amygdala

    d) Ventral tegmental area

  • VTA; nucleus accumbens

    Smoking nicotine acts on the ______ causing dopamine release in the ______.

  • voltage-gated calcium channels

    Nicotine activates & opens __________.

  • a4B2

    _______ is the receptor for responding to nicotine.

  • potency; binding affinity

    Varenicline has less _______ than Nicotine, but higher _______.

  • partial agonist of a4b2 receptor; prevents nicotine from binding; reduces craving/withdrawal; decreases reward from relapse

    Varenicline MOA?

  • f; can increase nausea

    Varenicline & NRT can work synergistically to reduce nicotine cravings. T/F?

  • NDRI; unicyclic

    Buproprion is a ________ & ________ antidepressant.

  • increases dopaminergic/noradrenergic signaling, mimics nicotines effects; non-competitive antagonist- diminishes reinforcement of nicotine

    Buproprion MOA?

  • d

    Bupropion is metabolized by _______.

    a) CYP2D6

    b) CYP3A4

    c) CYP2C19

    d) CYP2B6

  • agonist of presynaptic a2 receptors

    Clonidine MOA?

  • 5-HT & NE reuptake inhibition

    Nortriptyline MOA?

  • b,c

    Which have to be started before a patient's quit date?

    a) clonidine

    b) nortriptyline

    c) Bupropion

    d) Varenicline

  • b,c

    Which is Contraindicated in patients on MAOIs?

    a) clonidine

    b) nortriptyline

    c) Bupropion

    d) Varenicline

  • relief of withdrawal symptoms without spike; desensitizes nAChR- reduced effect of nicotine from cigs

    NRTs MOA? (2)

  • c

    Which is Contraindicated in patients with seizure disorders?

    a) clonidine

    b) nortriptyline

    c) Bupropion

    d) Varenicline

  • b

    Which requires HR & BP monitoring in elderly patients?

    a) clonidine

    b) nortriptyline

    c) Bupropion

    d) Varenicline

  • a

    Which has dose-dependent rise in AE's ?

    a) clonidine

    b) nortriptyline

    c) Bupropion

    d) Varenicline

  • c,d

    Which reduces pleasure from relapse?

    a) clonidine

    b) nortriptyline

    c) Bupropion

    d) Varenicline