c
Decreased effect with repeating doses; pharmacological adaptation.
a) substance use disorder
b) physical dependence
c) tolerance
a
Engages in compulsive repetition of the experience (drug-seeking).
a) substance use disorder
b) physical dependence
c) tolerance
b
Adaptive responses are now unopposed.
a) substance use disorder
b) physical dependence
c) tolerance
reinforcement
-neuronal activation in reward areas with compulsive repetition of use
DA, 5HT, glutamate, NE, endogenous opioids, GABA
Which NTs are involved in reinforcement? (6)
c
Creating a dislike of addicted drugs; through consequences or punishment
a) neurotransmitter manipulation
b) pharmacological substitution
c) aversive conditioning
b
Substituting one substance that stimulates the brain reward pathway with
another less addictive/less harmful.
a) neurotransmitter manipulation
b) pharmacological substitution
c) aversive conditioning
a
Manipulating NT in the reward pathway to modify cravings/withdrawal symptoms.
a) neurotransmitter manipulation
b) pharmacological substitution
c) aversive conditioning
reduce cravings/withdrawal symptoms, inhibit reinforcing effects
What are the goals of smoking cessation pharmacotherapy? (2)
NRT, varenicline, buproprion
What are the first-line therapies for smoking cessation? (3)
clonidine, nortriptyline
What are the second-line therapies? (2)
same dose of nicotine; increase time
The patch provides __________ but with an __________ release.
spike
Reinforcement =
dip
Craving =
d
Rewarding stimulus induces dopamine release from the ______.
a) prefrontal cortex
b) nucleus accumbens
c) amygdala
d) Ventral tegmental area
b
Responsible for regulating survival drives.
a) prefrontal cortex
b) nucleus accumbens
c) amygdala
d) Ventral tegmental area
c
Retains memory of pleasure.
a) prefrontal cortex
b) nucleus accumbens
c) amygdala
d) Ventral tegmental area
a
Part of the frontal lobe involved in many cognitive functions.
a) prefrontal cortex
b) nucleus accumbens
c) amygdala
d) Ventral tegmental area
VTA; nucleus accumbens
Smoking nicotine acts on the ______ causing dopamine release in the ______.
voltage-gated calcium channels
Nicotine activates & opens __________.
a4B2
_______ is the receptor for responding to nicotine.
potency; binding affinity
Varenicline has less _______ than Nicotine, but higher _______.
partial agonist of a4b2 receptor; prevents nicotine from binding; reduces craving/withdrawal; decreases reward from relapse
Varenicline MOA?
f; can increase nausea
Varenicline & NRT can work synergistically to reduce nicotine cravings. T/F?
NDRI; unicyclic
Buproprion is a ________ & ________ antidepressant.
increases dopaminergic/noradrenergic signaling, mimics nicotines effects; non-competitive antagonist- diminishes reinforcement of nicotine
Buproprion MOA?
d
Bupropion is metabolized by _______.
a) CYP2D6
b) CYP3A4
c) CYP2C19
d) CYP2B6
agonist of presynaptic a2 receptors
Clonidine MOA?
5-HT & NE reuptake inhibition
Nortriptyline MOA?
b,c
Which have to be started before a patient's quit date?
a) clonidine
b) nortriptyline
c) Bupropion
d) Varenicline
b,c
Which is Contraindicated in patients on MAOIs?
a) clonidine
b) nortriptyline
c) Bupropion
d) Varenicline
relief of withdrawal symptoms without spike; desensitizes nAChR- reduced effect of nicotine from cigs
NRTs MOA? (2)
c
Which is Contraindicated in patients with seizure disorders?
a) clonidine
b) nortriptyline
c) Bupropion
d) Varenicline
b
Which requires HR & BP monitoring in elderly patients?
a) clonidine
b) nortriptyline
c) Bupropion
d) Varenicline
a
Which has dose-dependent rise in AE's ?
a) clonidine
b) nortriptyline
c) Bupropion
d) Varenicline
c,d
Which reduces pleasure from relapse?
a) clonidine
b) nortriptyline
c) Bupropion
d) Varenicline