2023-12-06T04:16:57+03:00[Europe/Moscow] en true <p>infliximab, certolizumab, adalimumab, golimumab, etanercept</p>, <p>bind and inhibit TNF-a signaling; decreasing macrophage/T cell function</p>, <p>a</p>, <p>b</p>, <p>d,e</p>, <p>c</p>, <p>c</p>, <p>a</p>, <p>Abatacept </p>, <p>a fusion protein that binds to CD80/86; inhibiting the binding to CD28 and preventing the activation of T cells; no cytokine release </p>, <p>a</p>, <p>b</p>, <p>b</p>, <p>fatal infusion reactions, leukoencephalopathy, severe mucocutaneous reaction</p>, <p>e</p>, <p>e</p>, <p>d</p>, <p>chimeric anti-CD20; causing apoptosis of B lymphocytes </p>, <p>binds to and blocks soluble/mb-bound IL-6 receptors inhibiting IL-6 mediated T cell activation</p>, <p>tocilizumab, sarilumab </p>, <p>anakinra, canakinumab </p>, <p>b</p>, <p>a</p>, <p>B-cell cytotoxic agent </p>, <p>false</p>, <p>T-cell engages with APC; a signal is produced by CD28 on the T cell that interacts with CD80/86 on the APC; which activates T cells </p>, <p>a</p> flashcards
Pharmacology of RA Biologics

Pharmacology of RA Biologics

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  • infliximab, certolizumab, adalimumab, golimumab, etanercept

    What are the TNF-a-blocking agents? (5)

  • bind and inhibit TNF-a signaling; decreasing macrophage/T cell function

    TNF-a blockers MOA?

  • a

    Which is a dimeric fusion protein?

    a) Etanercept

    b) Certolizumab

    c) Infliximab

    d) Golimumab

    e) Adalimumab

  • b

    Which is an AB-fragment conjugated with PEG?

    a) Etanercept

    b) Certolizumab

    c) Infliximab

    d) Golimumab

    e) Adalimumab

  • d,e

    Which are the human mABs?

    a) Etanercept

    b) Certolizumab

    c) Infliximab

    d) Golimumab

    e) Adalimumab

  • c

    Which is the chimeric AB?

    a) Etanercept

    b) Certolizumab

    c) Infliximab

    d) Golimumab

    e) Adalimumab

  • c

    Which is administered via IV?

    a) Etanercept

    b) Certolizumab

    c) Infliximab

    d) Golimumab

    e) Adalimumab

  • a

    Which has the shortest half-life?

    a) Etanercept

    b) Certolizumab

    c) Infliximab

    d) Golimumab

    e) Adalimumab

  • Abatacept

    What is the T-cell modulating biologic?

  • a fusion protein that binds to CD80/86; inhibiting the binding to CD28 and preventing the activation of T cells; no cytokine release

    Abatacept MOA?

  • a

    Which is rarely used anymore in RA?

    a) T-cell Modulator

    b) TNF-a blockers

    c) IL-1 inhibitors

    d) B-cell cytotoxic

    e) Anti-IL-6R

  • b

    Which can exacerbate existing HF and is CI in class III/IV?

    a) T-cell Modulator

    b) TNF-a blockers

    c) Anti IL-1

    d) B-cell cytotoxic

    e) Anti-IL-6R

  • b

    Which class is susceptible to developing anti-drug antibodies?

    a) T-cell Modulator

    b) TNF-a blockers

    c) Anti IL-1

    d) B-cell cytotoxic

    e) Anti-IL-6R

  • fatal infusion reactions, leukoencephalopathy, severe mucocutaneous reaction

    What are the Boxed Warnings associated with Rituximab? (3)

  • e

    Which one requires patients to be screened for TB?

    a) T-cell Modulator

    b) TNF-a blockers

    c) Anti IL-1

    d) B-cell cytotoxic

    e) Anti-IL-6R

  • e

    Which one is CI with live vaccines?

    a) T-cell Modulator

    b) TNF-a blockers

    c) Anti IL-1

    d) B-cell cytotoxic

    e) Anti-IL-6R

  • d

    Which is indicated when patients fail to respond to 1 or more anti-TNF's?

    a) T-cell Modulator

    b) TNF-a blockers

    c) Anti IL-1

    d) B-cell cytotoxic

    e) Anti-IL-6R

  • chimeric anti-CD20; causing apoptosis of B lymphocytes

    Rituximab MOA?

  • binds to and blocks soluble/mb-bound IL-6 receptors inhibiting IL-6 mediated T cell activation

    Anti-IL-6R MOA?

  • tocilizumab, sarilumab

    What are the Anti-IL-6R MABs? (2)

  • anakinra, canakinumab

    What are the IL-1 inhibitors?

  • b

    Which one is a recombinant IL-1R antagonist?

    a) canakinumab

    b) anakinra

  • a

    Which one is a mAB against IL-1B?

    a) canakinumab

    b) anakinra

  • B-cell cytotoxic agent

    What kind of drug is Rituximab?

  • false

    TNF-a blockers have higher rates of infection than T-cell modulators. T/F?

  • T-cell engages with APC; a signal is produced by CD28 on the T cell that interacts with CD80/86 on the APC; which activates T cells

    How are T-cells activated? (3)

  • a

    Which one has the most improvement in treating Psoriatic Arthritis?

    a) T-cell Modulator

    b) TNF-a blockers

    c) Anti IL-1

    d) B-cell cytotoxic

    e) Anti-IL-6R