infliximab, certolizumab, adalimumab, golimumab, etanercept
What are the TNF-a-blocking agents? (5)
bind and inhibit TNF-a signaling; decreasing macrophage/T cell function
TNF-a blockers MOA?
a
Which is a dimeric fusion protein?
a) Etanercept
b) Certolizumab
c) Infliximab
d) Golimumab
e) Adalimumab
b
Which is an AB-fragment conjugated with PEG?
a) Etanercept
b) Certolizumab
c) Infliximab
d) Golimumab
e) Adalimumab
d,e
Which are the human mABs?
a) Etanercept
b) Certolizumab
c) Infliximab
d) Golimumab
e) Adalimumab
c
Which is the chimeric AB?
a) Etanercept
b) Certolizumab
c) Infliximab
d) Golimumab
e) Adalimumab
c
Which is administered via IV?
a) Etanercept
b) Certolizumab
c) Infliximab
d) Golimumab
e) Adalimumab
a
Which has the shortest half-life?
a) Etanercept
b) Certolizumab
c) Infliximab
d) Golimumab
e) Adalimumab
Abatacept
What is the T-cell modulating biologic?
a fusion protein that binds to CD80/86; inhibiting the binding to CD28 and preventing the activation of T cells; no cytokine release
Abatacept MOA?
a
Which is rarely used anymore in RA?
a) T-cell Modulator
b) TNF-a blockers
c) IL-1 inhibitors
d) B-cell cytotoxic
e) Anti-IL-6R
b
Which can exacerbate existing HF and is CI in class III/IV?
a) T-cell Modulator
b) TNF-a blockers
c) Anti IL-1
d) B-cell cytotoxic
e) Anti-IL-6R
b
Which class is susceptible to developing anti-drug antibodies?
a) T-cell Modulator
b) TNF-a blockers
c) Anti IL-1
d) B-cell cytotoxic
e) Anti-IL-6R
fatal infusion reactions, leukoencephalopathy, severe mucocutaneous reaction
What are the Boxed Warnings associated with Rituximab? (3)
e
Which one requires patients to be screened for TB?
a) T-cell Modulator
b) TNF-a blockers
c) Anti IL-1
d) B-cell cytotoxic
e) Anti-IL-6R
e
Which one is CI with live vaccines?
a) T-cell Modulator
b) TNF-a blockers
c) Anti IL-1
d) B-cell cytotoxic
e) Anti-IL-6R
d
Which is indicated when patients fail to respond to 1 or more anti-TNF's?
a) T-cell Modulator
b) TNF-a blockers
c) Anti IL-1
d) B-cell cytotoxic
e) Anti-IL-6R
chimeric anti-CD20; causing apoptosis of B lymphocytes
Rituximab MOA?
binds to and blocks soluble/mb-bound IL-6 receptors inhibiting IL-6 mediated T cell activation
Anti-IL-6R MOA?
tocilizumab, sarilumab
What are the Anti-IL-6R MABs? (2)
anakinra, canakinumab
What are the IL-1 inhibitors?
b
Which one is a recombinant IL-1R antagonist?
a) canakinumab
b) anakinra
a
Which one is a mAB against IL-1B?
a) canakinumab
b) anakinra
B-cell cytotoxic agent
What kind of drug is Rituximab?
false
TNF-a blockers have higher rates of infection than T-cell modulators. T/F?
T-cell engages with APC; a signal is produced by CD28 on the T cell that interacts with CD80/86 on the APC; which activates T cells
How are T-cells activated? (3)
a
Which one has the most improvement in treating Psoriatic Arthritis?
a) T-cell Modulator
b) TNF-a blockers
c) Anti IL-1
d) B-cell cytotoxic
e) Anti-IL-6R