2023-10-14T19:51:21+03:00[Europe/Moscow] en true <p>during replicative process</p>, <p>b</p>, <p>a</p>, <p>b</p>, <p>H1N1, H1N2, H3N2</p>, <p>enveloped ssRNA</p>, <p>d</p>, <p>b</p>, <p>a</p>, <p>M2 channel </p>, <p>b</p>, <p>HA; sialic acid </p>, <p>oseltamivir, zanamivir, peramivir </p>, <p>Baloxavir marboxil </p>, <p>amantadine, rimantadine </p>, <p>inhibit M2 ion channels; preventing uncoating/viral replication </p>, <p>catalytic head, stalk, transmembrane region, cytoplasmic tail </p>, <p>catalytic head </p>, <p>analogs of sialic acid that bind to NA and cause conformational change; limit release of virus from cell </p>, <p>within 48 hours of infection </p>, <p>endonuclease inhibitors, neuraminidase inhibitors</p>, <p>inhibits endonuclease-mediated cap snatching; interferes with viral RNA transcription </p>, <p>baloxavir marboxil, oseltamivir </p>, <p>a</p>, <p>b</p>, <p>b</p>, <p>b</p>, <p>d</p>, <p>d</p>, <p>b</p> flashcards
Pharmacology of Influenza

Pharmacology of Influenza

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  • during replicative process

    When are antivirals effective?

  • b

    Antivirals are

    a) cidal

    b) static

  • a

    Which causes Epidemics AND Pandemics?

    a) Influenza A

    b) Influenza B

    c) Influenza C

  • b

    Which is only in humans?

    a) Influenza A

    b) Influenza B

    c) Influenza C

  • H1N1, H1N2, H3N2

    What are the subtypes of Influenza A? (3)

  • enveloped ssRNA

    Influenza is an ________ virus

  • d

    Which contains hemagglutinin and neuraminidase?

    a) virion

    b) proteins

    c) spike

    d) envelope

  • b

    Which is responsible for binding and infection?

    a) Neuraminidase

    b) Hemagglutinin

  • a

    Which is responsible for releasing new virions from host cell?

    a) Neuraminidase

    b) Hemagglutinin

  • M2 channel

    -involved in the uncoating process and allows for proton entry into the virus

  • b

    Influenza A & B vaccines contain _______.

    a) Neuraminidase

    b) Hemagglutinin

  • HA; sialic acid

    When a virus reaches a potential host cell, it uses ______ to bind surface

    glycans that contain terminal _________ residues.

  • oseltamivir, zanamivir, peramivir

    What are the neuraminidase inhibitors (3)?

  • Baloxavir marboxil

    What is the endonuclease inhibitor?

  • amantadine, rimantadine

    What are the Adamantanes? (2)

  • inhibit M2 ion channels; preventing uncoating/viral replication

    Adamantanes MOA?

  • catalytic head, stalk, transmembrane region, cytoplasmic tail

    What are the 4 distinct structural domains of an NA spike?

  • catalytic head

    Sialic acid is located on the ________.

  • analogs of sialic acid that bind to NA and cause conformational change; limit release of virus from cell

    Neuraminidase inhibitors MOA?

  • within 48 hours of infection

    Neuraminidase inhibitors can accelerate the resolution of symptoms if

    given ____________.

  • endonuclease inhibitors, neuraminidase inhibitors

    Which class of antivirals can be used for treatment AND prophylaxis? (2)

  • inhibits endonuclease-mediated cap snatching; interferes with viral RNA transcription

    Endonuclease inhibitor MOA?

  • baloxavir marboxil, oseltamivir

    Which antivirals are oral prodrugs? (2)

  • a

    Which is given via inhalation?

    a) Zanamivir

    b) Peramivir

    c) Baloxavir Marboxil

    d) Oseltamivir

  • b

    Which is given via IV?

    a) Zanamivir

    b) Peramivir

    c) Baloxavir Marboxil

    d) Oseltamivir

  • b

    Which neuraminidase inhibitor CANNOT be used for prophylaxis?

    a) Zanamivir

    b) Peramivir

    c) Baloxavir Marboxil

    d) Oseltamivir

  • b

    Which can bind to multiple binding sites & better for resistant viruses?

    a) Zanamivir

    b) Peramivir

    c) Baloxavir Marboxil

    d) Oseltamivir

  • d

    Which can cause neuropsychiatric effects in children?

    a) Zanamivir

    b) Peramivir

    c) Baloxavir Marboxil

    d) Oseltamivir

  • d

    Which is an analog of Sialic Acid?

    a) Zanamivir

    b) Peramivir

    c) Baloxavir Marboxil

    d) Oseltamivir

  • b

    Which is indicated in severely ill patients?

    a) Zanamivir

    b) Peramivir

    c) Baloxavir Marboxil

    d) Oseltamivir