during replicative process
When are antivirals effective?
b
Antivirals are
a) cidal
b) static
a
Which causes Epidemics AND Pandemics?
a) Influenza A
b) Influenza B
c) Influenza C
b
Which is only in humans?
a) Influenza A
b) Influenza B
c) Influenza C
H1N1, H1N2, H3N2
What are the subtypes of Influenza A? (3)
enveloped ssRNA
Influenza is an ________ virus
d
Which contains hemagglutinin and neuraminidase?
a) virion
b) proteins
c) spike
d) envelope
b
Which is responsible for binding and infection?
a) Neuraminidase
b) Hemagglutinin
a
Which is responsible for releasing new virions from host cell?
a) Neuraminidase
b) Hemagglutinin
M2 channel
-involved in the uncoating process and allows for proton entry into the virus
b
Influenza A & B vaccines contain _______.
a) Neuraminidase
b) Hemagglutinin
HA; sialic acid
When a virus reaches a potential host cell, it uses ______ to bind surface
glycans that contain terminal _________ residues.
oseltamivir, zanamivir, peramivir
What are the neuraminidase inhibitors (3)?
Baloxavir marboxil
What is the endonuclease inhibitor?
amantadine, rimantadine
What are the Adamantanes? (2)
inhibit M2 ion channels; preventing uncoating/viral replication
Adamantanes MOA?
catalytic head, stalk, transmembrane region, cytoplasmic tail
What are the 4 distinct structural domains of an NA spike?
catalytic head
Sialic acid is located on the ________.
analogs of sialic acid that bind to NA and cause conformational change; limit release of virus from cell
Neuraminidase inhibitors MOA?
within 48 hours of infection
Neuraminidase inhibitors can accelerate the resolution of symptoms if
given ____________.
endonuclease inhibitors, neuraminidase inhibitors
Which class of antivirals can be used for treatment AND prophylaxis? (2)
inhibits endonuclease-mediated cap snatching; interferes with viral RNA transcription
Endonuclease inhibitor MOA?
baloxavir marboxil, oseltamivir
Which antivirals are oral prodrugs? (2)
a
Which is given via inhalation?
a) Zanamivir
b) Peramivir
c) Baloxavir Marboxil
d) Oseltamivir
b
Which is given via IV?
a) Zanamivir
b) Peramivir
c) Baloxavir Marboxil
d) Oseltamivir
b
Which neuraminidase inhibitor CANNOT be used for prophylaxis?
a) Zanamivir
b) Peramivir
c) Baloxavir Marboxil
d) Oseltamivir
b
Which can bind to multiple binding sites & better for resistant viruses?
a) Zanamivir
b) Peramivir
c) Baloxavir Marboxil
d) Oseltamivir
d
Which can cause neuropsychiatric effects in children?
a) Zanamivir
b) Peramivir
c) Baloxavir Marboxil
d) Oseltamivir
d
Which is an analog of Sialic Acid?
a) Zanamivir
b) Peramivir
c) Baloxavir Marboxil
d) Oseltamivir
b
Which is indicated in severely ill patients?
a) Zanamivir
b) Peramivir
c) Baloxavir Marboxil
d) Oseltamivir