2023-10-27T01:26:06+03:00[Europe/Moscow] en true <p>8.5-10.5 mg/dL</p>, <p>alkalosis </p>, <p>&lt;4.4 mg/dL</p>, <p>magnesium deficiency; elevated serum phosphate</p>, <p>cholecalciferol </p>, <p>Ergocalciferol </p>, <p>liver; kidney </p>, <p>calcifediol; calcitriol </p>, <p>GI disease </p>, <p>&lt;20 ng/mL</p>, <p>phenobarbital, phenytoin, ketoconazole </p>, <p>calcitonin, cinacalcet </p>, <p>aminoglycosides, cisplatin, amphotericin b</p>, <p>denosumab, bisphosphonates </p>, <p>reduced: calcium absorption in GI, calcium deposition in bones, calcium reabsorption in kidney</p>, <p>calcium carbonate</p>, <p>b</p>, <p>b</p>, <p>calcium chloride; calcium gluconate </p>, <p>&gt;30 ng/mL</p>, <p>calcium citrate</p> flashcards
Pharmacology of Hypocalcemia

Pharmacology of Hypocalcemia

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  • 8.5-10.5 mg/dL

    What is the normal serum concentration of calcium?

  • alkalosis

    An increase in the binding of calcium to albumin will result in what?

  • <4.4 mg/dL

    Hypocalcemia is defined as having an ionized calcium of?

  • magnesium deficiency; elevated serum phosphate

    What electrolyte abnormalities can cause hypocalcemia? (2)

  • cholecalciferol

    Vitamin D3

  • Ergocalciferol

    Vitamin D2

  • liver; kidney

    Vitamin D3 is metabolized in what organs? (2)

  • calcifediol; calcitriol

    When Vit D3 is metabolized it becomes ________; then it is metabolized

    again into ________.

  • GI disease

    What is the most common cause of Vit D deficiency?

  • <20 ng/mL

    Vitamin D deficiency =

  • phenobarbital, phenytoin, ketoconazole

    Which drugs increase the metabolism of Vitamin D? (3)

  • calcitonin, cinacalcet

    Which drugs alter PTH signaling? (2)

  • aminoglycosides, cisplatin, amphotericin b

    Which drugs cause hypomagnesemia/nephrotoxicity? (3)

  • denosumab, bisphosphonates

    Which drugs can block bone resorption? (2)

  • reduced: calcium absorption in GI, calcium deposition in bones, calcium reabsorption in kidney

    Vitamin D deficiency can cause: (3)

  • calcium carbonate

    -calcium formulation with 40% elemental calcium

  • b

    Which requires acidity?

    a) calcium citrate

    b) calcium carbonate

  • b

    Which is active and DOESN'T require bioactivation?

    a) cholecalciferol

    b) calcitriol

    c) ergocalciferol

  • calcium chloride; calcium gluconate

    What are the IV calcium formulations? (2)

  • >30 ng/mL

    What is the target range for Vitamin D?

  • calcium citrate

    -calcium formulation with 21% elemental