8.5-10.5 mg/dL
What is the normal serum concentration of calcium?
alkalosis
An increase in the binding of calcium to albumin will result in what?
<4.4 mg/dL
Hypocalcemia is defined as having an ionized calcium of?
magnesium deficiency; elevated serum phosphate
What electrolyte abnormalities can cause hypocalcemia? (2)
cholecalciferol
Vitamin D3
Ergocalciferol
Vitamin D2
liver; kidney
Vitamin D3 is metabolized in what organs? (2)
calcifediol; calcitriol
When Vit D3 is metabolized it becomes ________; then it is metabolized
again into ________.
GI disease
What is the most common cause of Vit D deficiency?
<20 ng/mL
Vitamin D deficiency =
phenobarbital, phenytoin, ketoconazole
Which drugs increase the metabolism of Vitamin D? (3)
calcitonin, cinacalcet
Which drugs alter PTH signaling? (2)
aminoglycosides, cisplatin, amphotericin b
Which drugs cause hypomagnesemia/nephrotoxicity? (3)
denosumab, bisphosphonates
Which drugs can block bone resorption? (2)
reduced: calcium absorption in GI, calcium deposition in bones, calcium reabsorption in kidney
Vitamin D deficiency can cause: (3)
calcium carbonate
-calcium formulation with 40% elemental calcium
b
Which requires acidity?
a) calcium citrate
b) calcium carbonate
b
Which is active and DOESN'T require bioactivation?
a) cholecalciferol
b) calcitriol
c) ergocalciferol
calcium chloride; calcium gluconate
What are the IV calcium formulations? (2)
>30 ng/mL
What is the target range for Vitamin D?
calcium citrate
-calcium formulation with 21% elemental