Hosam Mohamed-
increased potassium intake, decreased excretion, tubular unresponsiveness to aldosterone, redistribution of potassium into ECF
What is the etiology of hyperkalemia? (4)
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patients on dialysis or CKD;
What kind of patients can have an increased dietary intake of potassium?
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sickle cell, lupus, amyloidosis
Which diseases can cause tubular unresponsiveness to aldosterone? (3)
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metabolic acidosis, CKD, D2M
Which diseases can cause potassium to be redistributed into the ECF? (3)
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ACEi/ARBs, MRAs, K+ sparing diuretics, NSAIDs, aliskiren
Which medications can cause hyperkalemia? (5)
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potassium binding resins to increase K+ elimination
How do we treat hyperkalemia?
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sodium polystyrene sulfonate, patiromer, sodium zirconium cyclosilicate
What are the potassium binders? (3)
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exchange Na+ or Ca+ for K+ to increase fecal K+ elimination
K+ binders MOA?
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constipation, edema
What are AE's of K+ binders? (2)
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Patiromer; also binds Mg2+
Which potassium binder has the highest risk of constipation? Why?
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patients with GI issues
Which patients do we avoid K+ binders in?
