Hosam Mohamed-
metabolic; acute arthritis
Gout is a _______ disorder with recurrent episodes of _________.
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when shedding happens
When do gout attacks occur?
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synoviocytes phagocytize urate, release PGs/IL-1, chemotaxis of PMN leukocytes that amplify inflammation, infiltration of macrophages/more inflammation
What is our body's response to Acute Gout Attacks? (4)
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Purine, xanthine, xanthine oxidase, uric acid
What is the metabolic pathway of Uric acid? (4)
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hyperuricemia from underproduction of low-soluble urate
How does gout occur in most patients?
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NSAIDs, Corticosteroids, Colchicine
What are the First-line drugs for acute gout? (3)
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indomethacin, oxaprozin
Which NSAIDs are most commonly used in gout? (2)
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allopurinol, febuxostat, pegloticase
Which drugs block uric acid production? (3)
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b
Which drug binds to intracellular tubulin; preventing microtubule polymerization?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
-
b
Which one does NOT alter metabolism/excretion of urates?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
-
b
Which is a major substrate of CYP3A4 & P-GP?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
-
a
Which is the preferred therapy for in-between acute episodes?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
-
a
Which can precipitate gout?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
-
inhibits metabolism of probenecid/warfarin, increases hepatic iron, increase effect of chemotherapy purines
What are important drug considerations regarding Allopurinol? (3)
-
a,d
Which are used early, in combo with Colchicine to prevent gout flares?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
-
d
Which has the longest half-life?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
-
converts uric acid to allantoin to be renally eliminated
Pegloticase MOA?
-
Rasburicase
_______ is for hyperuricemia associated with malignancy.
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e
Which is a potent & selective XO inhibitor?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
-
only for patients who have failed/can't tolerate allopurinol
What is the indication for Febuxostat?
-
e
Which has a BW for increased risk of death?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
-
e
Which can cause liver toxicity?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
-
c
Which can cause kidney stones?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
-
a
Where does Probenecid work in the renal tubules?
a) PCT
b) Loop of Henle
c) DCT
d) Collecting Duct
-
d
Which has a BW for infusion reactions?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
-
d
Which is a rapid-acting IV drug?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
