metabolic; acute arthritis
Gout is a _______ disorder with recurrent episodes of _________.
when shedding happens
When do gout attacks occur?
synoviocytes phagocytize urate, release PGs/IL-1, chemotaxis of PMN leukocytes that amplify inflammation, infiltration of macrophages/more inflammation
What is our body's response to Acute Gout Attacks? (4)
Purine, xanthine, xanthine oxidase, uric acid
What is the metabolic pathway of Uric acid? (4)
hyperuricemia from underproduction of low-soluble urate
How does gout occur in most patients?
NSAIDs, Corticosteroids, Colchicine
What are the First-line drugs for acute gout? (3)
indomethacin, oxaprozin
Which NSAIDs are most commonly used in gout? (2)
allopurinol, febuxostat, pegloticase
Which drugs block uric acid production? (3)
b
Which drug binds to intracellular tubulin; preventing microtubule polymerization?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
b
Which one does NOT alter metabolism/excretion of urates?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
b
Which is a major substrate of CYP3A4 & P-GP?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
a
Which is the preferred therapy for in-between acute episodes?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
a
Which can precipitate gout?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
inhibits metabolism of probenecid/warfarin, increases hepatic iron, increase effect of chemotherapy purines
What are important drug considerations regarding Allopurinol? (3)
a,d
Which are used early, in combo with Colchicine to prevent gout flares?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
d
Which has the longest half-life?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
converts uric acid to allantoin to be renally eliminated
Pegloticase MOA?
Rasburicase
_______ is for hyperuricemia associated with malignancy.
e
Which is a potent & selective XO inhibitor?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
only for patients who have failed/can't tolerate allopurinol
What is the indication for Febuxostat?
e
Which has a BW for increased risk of death?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
e
Which can cause liver toxicity?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
c
Which can cause kidney stones?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
a
Where does Probenecid work in the renal tubules?
a) PCT
b) Loop of Henle
c) DCT
d) Collecting Duct
d
Which has a BW for infusion reactions?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat
d
Which is a rapid-acting IV drug?
a) allopurinol
b) colchicine
c) probenecid
d) pegloticase
e) febuxostat