2023-12-03T21:23:54+03:00[Europe/Moscow] en true <p>unconsciousness, amnesia, analgesia, inhibition of autonomic reflexes, skeletal muscle relaxation</p>, <p>should induce rapid smooth loss of consciousness, rapidly reversible, wide margin of safety</p>, <p>inhaled + IV drugs</p>, <p>increase inhibition through GABA; decrease excitation</p>, <p>decreased BP, reduced RR, hypothermia, N/V</p>, <p>-ane suffix </p>, <p>nitrous oxide</p>, <p>propofol, fospropofol, etomidate, ketamine</p>, <p>methohexital</p>, <p>Midazolam, Dexmedetomidine </p>, <p>IV</p>, <p>GABA A agonism</p>, <p>c</p>, <p>b</p>, <p>b</p>, <p>a</p>, <p>a</p>, <p>fast; acidosis; muscle contraction </p>, <p>GABA A positive allosteric modulation </p>, <p>anti-emetic, injection site pain, narrow TI</p>, <p>b</p>, <p>b</p>, <p>hypnotic; analgesic </p>, <p>b</p>, <p>a</p>, <p>a</p>, <p>c</p>, <p>c,d</p>, <p>c</p>, <p>d</p>, <p>d</p>, <p>d</p>, <p>b</p>, <p>b</p>, <p>a,c</p>, <p>flumazenil </p>, <p>c</p>, <p>prolong sedation in hospitalized patients, emergence delirium/agitation, sedation/GA</p>, <p>opioid; benzo</p> flashcards
Pharmacology of General Anesthetics

Pharmacology of General Anesthetics

Customize
collection saved
Share
Long Term Learning Spaced Repetition
Add to Long Term Learning Desk
Fast learning Repeat this set of flashcards
Preview Test Spell
Play
Match
Review

  • unconsciousness, amnesia, analgesia, inhibition of autonomic reflexes, skeletal muscle relaxation

    What are the desired effects of General Anesthetics? (5)

  • should induce rapid smooth loss of consciousness, rapidly reversible, wide margin of safety

    What are the characteristics of an ideal anesthetic drug? (3)

  • inhaled + IV drugs

    Balanced Anesthesia =

  • increase inhibition through GABA; decrease excitation

    What is the MOA of General Anesthetics?

  • decreased BP, reduced RR, hypothermia, N/V

    What are the negative effects of general anesthesia? (4)

  • -ane suffix

    What are the volatile GA?

  • nitrous oxide

    What is the gaseous GA?

  • propofol, fospropofol, etomidate, ketamine

    What are the PO/IV GA? (4)

  • methohexital

    What is the Barbituate?

  • Midazolam, Dexmedetomidine

    What are the Benzodiazepines? (2)

  • IV

    ______ drugs are preferred for induction.

  • GABA A agonism

    MOA of Inhaled Anesthetics?

  • c

    Which are used for GA induction and maintenance of surgical

    procedures?

    a) benzodiazepines

    b) barbituates

    c) inhaled anesthetics

    d) IV anesthetics

  • b

    Which inhaled anesthetic can cause fulminant hepatic necrosis?

    a) Enflurane

    b) Halothane

    c) Nitrous oxide

  • b

    Which inhaled anesthetic can cause malignant hyperthermia when

    combined with succinylcholine?

    a) Enflurane

    b) Halothane

    c) Nitrous oxide

  • a

    Which inhaled anesthetic can cause nephrotoxicity?

    a) Enflurane

    b) Halothane

    c) Nitrous oxide

  • a

    Which inhaled anesthetic can cause seizures?

    a) Enflurane

    b) Halothane

    c) Nitrous oxide

  • fast; acidosis; muscle contraction

    Dantrolene requires ______ administration to control _______ and _______ when treating malignant hyperthermia.

  • GABA A positive allosteric modulation

    Propofol MOA?

  • anti-emetic, injection site pain, narrow TI

    What are the notable features of Propofol? (3)

  • b

    Which has a fast recovery and no hangover due to high plasma

    clearance?

    a) Fospropofol

    b) Propofol

    c) Etomidate

    d) Ketamine

  • b

    Which has the biggest decrease in systemic BP?

    a) Fospropofol

    b) Propofol

    c) Etomidate

    d) Ketamine

  • hypnotic; analgesic

    Propofol is a ______, but NOT an _______.

  • b

    Which is given with Lidocaine for injection site pain?

    a) Fospropofol

    b) Propofol

    c) Etomidate

    d) Ketamine

  • a

    Which is a water-soluble prodrug?

    a) Fospropofol

    b) Propofol

    c) Etomidate

    d) Ketamine

  • a

    Which has NO injection site pain?

    a) Fospropofol

    b) Propofol

    c) Etomidate

    d) Ketamine

  • c

    Which is used in patients with reduced cardiac function or respiratory reserve?

    a) Fospropofol

    b) Propofol

    c) Etomidate

    d) Ketamine

  • c,d

    Which are used for conscious sedation?

    a) Fospropofol

    b) Propofol

    c) Etomidate

    d) Ketamine

  • c

    Which can suppress the endocrine system?

    a) Fospropofol

    b) Propofol

    c) Etomidate

    d) Ketamine

  • d

    Which has unpleasant emergence reactions?

    a) Fospropofol

    b) Propofol

    c) Etomidate

    d) Ketamine

  • d

    Which has a MOA related to NMDA antagonism?

    a) Fospropofol

    b) Propofol

    c) Etomidate

    d) Ketamine

  • d

    Which provides analgesia?

    a) Fospropofol

    b) Propofol

    c) Etomidate

    d) Ketamine

  • b

    Which is used for induction?

    a) midazolam

    b) methohexital

    c) dexmedetomidine

  • b

    Which causes the most CNS depression?

    a) midazolam

    b) methohexital

    c) dexmedetomidine

  • a,c

    Which are used as anxiolytics?

    a) midazolam

    b) methohexital

    c) dexmedetomidine

  • flumazenil

    How do we reverse Midazolam?

  • c

    Which is an A2 agonist?

    a) midazolam

    b) methohexital

    c) dexmedetomidine

  • prolong sedation in hospitalized patients, emergence delirium/agitation, sedation/GA

    What are the main clinical applications of Dexmedetomidine? (3)

  • opioid; benzo

    Adding an A2 agonist to a sedation regimen can greatly reduce _____ & _____ requirements.