2023-10-14T19:11:08+03:00[Europe/Moscow] en true <p>nirmatrelvir + ritonavir </p>, <p>paxlovid, remdesivir, molnupiravir </p>, <p>dexamethasone, Tocilizumab, baricitinib </p>, <p>MPRO</p>, <p>b</p>, <p>CYP3A4 inhibitor; nirmatrelvir </p>, <p>within 5 days of symptom onset</p>, <p>a,b</p>, <p>a,b</p>, <p>inhibit viral RNA polymerase; causes chain termination </p>, <p>d</p>, <p>d</p>, <p>d</p>, <p>transaminase levels; prothrombin time </p>, <p>c</p>, <p>a cytidine nucleoside analog uptaken by viral RNA-dependent RNA polymerase causing lethal mutagenesis; inhibiting viral replication </p>, <p>c</p>, <p>c</p>, <p>b</p>, <p>a</p>, <p>c</p>, <p>IV tocilizumab; dexamethasone </p>, <p>bebtelovimab, Evushield </p>, <p>tixagevimab + cilgavimab </p> flashcards
Pharmacology of COVID-19

Pharmacology of COVID-19

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  • nirmatrelvir + ritonavir

    Paxlovid =

  • paxlovid, remdesivir, molnupiravir

    What are the antivirals used against COVID? (3)

  • dexamethasone, Tocilizumab, baricitinib

    What are the immunomodulatory agents used against COVID-19? (3)

  • MPRO

    -a viral protease responsible for cleaving polyprotein precursors & essential

    for viral replication

  • b

    Which is a protease inhibitor active against MPRO?

    a) ritonavir

    b) nirmatrelvir

    c)molunpiravir

    d) remdesivir

  • CYP3A4 inhibitor; nirmatrelvir

    Ritonavir is a strong _________ & boosts the half-life & concentrations of _________.

  • within 5 days of symptom onset

    When do we use Paxlovid?

  • a,b

    Which has an AE of taste disturbances?

    a) ritonavir

    b) nirmatrelvir

    c)molunpiravir

    d) remdesivir

  • a,b

    Which has a boxed warning for DDI?

    a) ritonavir

    b) nirmatrelvir

    c)molunpiravir

    d) remdesivir

  • inhibit viral RNA polymerase; causes chain termination

    Remdesivir MOA?

  • d

    Which is a broad-spectrum antiviral?

    a) ritonavir

    b) nirmatrelvir

    c)molunpiravir

    d) remdesivir

  • d

    Which is used for prophylaxis of coronavirus infections?

    a) ritonavir

    b) nirmatrelvir

    c)molunpiravir

    d) remdesivir

  • d

    Which is administered via IV?

    a) ritonavir

    b) nirmatrelvir

    c)molunpiravir

    d) remdesivir

  • transaminase levels; prothrombin time

    Remdesivir can increase _______ & ________.

  • c

    Which is a prodrug?

    a) ritonavir

    b) nirmatrelvir

    c)molunpiravir

    d) remdesivir

  • a cytidine nucleoside analog uptaken by viral RNA-dependent RNA polymerase causing lethal mutagenesis; inhibiting viral replication

    Molnupiravir MOA?

  • c

    Which is used to prevent death in people who are at high risk for severe

    COVID-19?

    a) ritonavir

    b) nirmatrelvir

    c)molunpiravir

    d) remdesivir

  • c

    Which disrupts the JAK-STAT signaling pathway?

    a) Tocilizumab

    b) Dexamethasone

    c) Baricitinib

  • b

    Mitigates COVID-19-induced systemic hyperinflammatory response.

    a) Tocilizumab

    b) Dexamethasone

    c) Baricitinib

  • a

    IL-6 blocker that is effective at inhibiting cytokine storm.

    a) Tocilizumab

    b) Dexamethasone

    c) Baricitinib

  • c

    Which inhibits inflammatory gene transcription?

    a) Tocilizumab

    b) Dexamethasone

    c) Baricitinib

  • IV tocilizumab; dexamethasone

    ___________ + _________ is used in hospitalized patients.

  • bebtelovimab, Evushield

    Which mAB cocktails are useful against the Omicron variant? (2)

  • tixagevimab + cilgavimab

    Evushield =