nirmatrelvir + ritonavir
Paxlovid =
paxlovid, remdesivir, molnupiravir
What are the antivirals used against COVID? (3)
dexamethasone, Tocilizumab, baricitinib
What are the immunomodulatory agents used against COVID-19? (3)
MPRO
-a viral protease responsible for cleaving polyprotein precursors & essential
for viral replication
b
Which is a protease inhibitor active against MPRO?
a) ritonavir
b) nirmatrelvir
c)molunpiravir
d) remdesivir
CYP3A4 inhibitor; nirmatrelvir
Ritonavir is a strong _________ & boosts the half-life & concentrations of _________.
within 5 days of symptom onset
When do we use Paxlovid?
a,b
Which has an AE of taste disturbances?
a) ritonavir
b) nirmatrelvir
c)molunpiravir
d) remdesivir
a,b
Which has a boxed warning for DDI?
a) ritonavir
b) nirmatrelvir
c)molunpiravir
d) remdesivir
inhibit viral RNA polymerase; causes chain termination
Remdesivir MOA?
d
Which is a broad-spectrum antiviral?
a) ritonavir
b) nirmatrelvir
c)molunpiravir
d) remdesivir
d
Which is used for prophylaxis of coronavirus infections?
a) ritonavir
b) nirmatrelvir
c)molunpiravir
d) remdesivir
d
Which is administered via IV?
a) ritonavir
b) nirmatrelvir
c)molunpiravir
d) remdesivir
transaminase levels; prothrombin time
Remdesivir can increase _______ & ________.
c
Which is a prodrug?
a) ritonavir
b) nirmatrelvir
c)molunpiravir
d) remdesivir
a cytidine nucleoside analog uptaken by viral RNA-dependent RNA polymerase causing lethal mutagenesis; inhibiting viral replication
Molnupiravir MOA?
c
Which is used to prevent death in people who are at high risk for severe
COVID-19?
a) ritonavir
b) nirmatrelvir
c)molunpiravir
d) remdesivir
c
Which disrupts the JAK-STAT signaling pathway?
a) Tocilizumab
b) Dexamethasone
c) Baricitinib
b
Mitigates COVID-19-induced systemic hyperinflammatory response.
a) Tocilizumab
b) Dexamethasone
c) Baricitinib
a
IL-6 blocker that is effective at inhibiting cytokine storm.
a) Tocilizumab
b) Dexamethasone
c) Baricitinib
c
Which inhibits inflammatory gene transcription?
a) Tocilizumab
b) Dexamethasone
c) Baricitinib
IV tocilizumab; dexamethasone
___________ + _________ is used in hospitalized patients.
bebtelovimab, Evushield
Which mAB cocktails are useful against the Omicron variant? (2)
tixagevimab + cilgavimab
Evushield =