2023-09-20T02:20:08+03:00[Europe/Moscow] en true <p>procainamide</p>, <p>lidocaine, Mexiletine </p>, <p>Flecainide, Propafenone </p>, <p> blockade of Na+ channels; slowing ventricular conduction, decreasing automaticity in non-nodal cells, and increasing refractoriness</p>, <p>a</p>, <p>b</p>, <p>c</p>, <p>b</p>, <p>b</p>, <p>a</p>, <p>a</p>, <p>b</p>, <p>b</p>, <p>c</p>, <p>IV; IM</p>, <p>a</p>, <p>e</p>, <p>b</p>, <p>d,e</p>, <p>agranulocytosis, drug-induced lupus</p>, <p>c</p>, <p>increase the amount of time for contraction to occur and increase refractory period </p>, <p>c</p>, <p>a</p>, <p>b</p>, <p>a</p>, <p>c</p> flashcards
Pharmacology of Class 1: sodium channel blockers

Pharmacology of Class 1: sodium channel blockers

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  • procainamide

    What are the Class IA anti- arrhythmic drugs?

  • lidocaine, Mexiletine

    What are the Class IB anti - arrhythmic drugs? (2)

  • Flecainide, Propafenone

    What are the Class IC anti - arrhythmic drugs? (2)

  • blockade of Na+ channels; slowing ventricular conduction, decreasing automaticity in non-nodal cells, and increasing refractoriness

    Class I-Anti - Arrhythmics MOA?

  • a

    Which class has intermediate blockade?

    a) Class IA

    b) Class IB

    c) Class IC

  • b

    Which class has the weakest blockade?

    a) Class IA

    b) Class IB

    c) Class IC

  • c

    Which class has the strongest blockade?

    a) Class IA

    b) Class IB

    c) Class IC

  • b

    Which primarily acts on inactivated channels?

    a) Class IA

    b) Class IB

    c) Class IC

  • b

    Which is more effective on cells with longer AP, like Purkinje Fibers or

    ventricular cells?

    a) Class IA

    b) Class IB

    c) Class IC

  • a

    Which have moderate K+ channel blockade?

    a) Class IA

    b) Class IB

    c) Class IC

  • a

    Which class prolong action potential duration?

    a) Class IA

    b) Class IB

    c) Class IC

  • b

    Which has very high first pass metabolism?

    a) procainamide

    b) lidocaine

    c) mexiletine

    d) flecainide

    e) Propaefenone

  • b

    Which is the least cardiotoxic?

    a) procainamide

    b) lidocaine

    c) mexiletine

    d) flecainide

    e) Propaefenone

  • c

    __________ is orally active and an analong of Lidocaine.

    a) procainamide

    b) lidocaine

    c) mexiletine

    d) flecainide

    e) Propaefenone

  • IV; IM

    Lidocaine is available _____ or ______.

  • a

    Which has the highest risk of QTc prolongation & TDP ?

    a) procainamide

    b) lidocaine

    c) mexiletine

    d) flecainide

    e) Propaefenone

  • e

    Which has weak beta blocking activity?

    a) procainamide

    b) lidocaine

    c) mexiletine

    d) flecainide

    e) Propaefenone

  • b

    Which can have CNS SE's ?

    a) Class IA

    b) Class IB

    c) Class IC

  • d,e

    Which can worsen/cause cardiac arrhythmias?

    a) procainamide

    b) lidocaine

    c) mexiletine

    d) flecainide

    e) Propaefenone

  • agranulocytosis, drug-induced lupus

    Non-Cardiac AE's of Procainamide?

  • c

    Which has high pro-arrhythmic effects?

    a) Class IA

    b) Class IB

    c) Class IC

  • increase the amount of time for contraction to occur and increase refractory period

    What is the clinical mechanism behind Na+ channel blockers?

  • c

    Which class have NO effect on AP/ERP?

    a) Class IA

    b) Class IB

    c) Class IC

  • a

    Which class increases ERP?

    a) Class IA

    b) Class IB

    c) Class IC

  • b

    Which class shortens the AP duration?

    a) Class IA

    b) Class IB

    c) Class IC

  • a

    Which class shortens phase 3?

    a) Class IA

    b) Class IB

    c) Class IC

  • c

    Which class increases QRS duration?

    a) Class IA

    b) Class IB

    c) Class IC