procainamide
What are the Class IA anti- arrhythmic drugs?
lidocaine, Mexiletine
What are the Class IB anti - arrhythmic drugs? (2)
Flecainide, Propafenone
What are the Class IC anti - arrhythmic drugs? (2)
blockade of Na+ channels; slowing ventricular conduction, decreasing automaticity in non-nodal cells, and increasing refractoriness
Class I-Anti - Arrhythmics MOA?
a
Which class has intermediate blockade?
a) Class IA
b) Class IB
c) Class IC
b
Which class has the weakest blockade?
a) Class IA
b) Class IB
c) Class IC
c
Which class has the strongest blockade?
a) Class IA
b) Class IB
c) Class IC
b
Which primarily acts on inactivated channels?
a) Class IA
b) Class IB
c) Class IC
b
Which is more effective on cells with longer AP, like Purkinje Fibers or
ventricular cells?
a) Class IA
b) Class IB
c) Class IC
a
Which have moderate K+ channel blockade?
a) Class IA
b) Class IB
c) Class IC
a
Which class prolong action potential duration?
a) Class IA
b) Class IB
c) Class IC
b
Which has very high first pass metabolism?
a) procainamide
b) lidocaine
c) mexiletine
d) flecainide
e) Propaefenone
b
Which is the least cardiotoxic?
a) procainamide
b) lidocaine
c) mexiletine
d) flecainide
e) Propaefenone
c
__________ is orally active and an analong of Lidocaine.
a) procainamide
b) lidocaine
c) mexiletine
d) flecainide
e) Propaefenone
IV; IM
Lidocaine is available _____ or ______.
a
Which has the highest risk of QTc prolongation & TDP ?
a) procainamide
b) lidocaine
c) mexiletine
d) flecainide
e) Propaefenone
e
Which has weak beta blocking activity?
a) procainamide
b) lidocaine
c) mexiletine
d) flecainide
e) Propaefenone
b
Which can have CNS SE's ?
a) Class IA
b) Class IB
c) Class IC
d,e
Which can worsen/cause cardiac arrhythmias?
a) procainamide
b) lidocaine
c) mexiletine
d) flecainide
e) Propaefenone
agranulocytosis, drug-induced lupus
Non-Cardiac AE's of Procainamide?
c
Which has high pro-arrhythmic effects?
a) Class IA
b) Class IB
c) Class IC
increase the amount of time for contraction to occur and increase refractory period
What is the clinical mechanism behind Na+ channel blockers?
c
Which class have NO effect on AP/ERP?
a) Class IA
b) Class IB
c) Class IC
a
Which class increases ERP?
a) Class IA
b) Class IB
c) Class IC
b
Which class shortens the AP duration?
a) Class IA
b) Class IB
c) Class IC
a
Which class shortens phase 3?
a) Class IA
b) Class IB
c) Class IC
c
Which class increases QRS duration?
a) Class IA
b) Class IB
c) Class IC