2023-09-28T02:29:07+03:00[Europe/Moscow] en true <p>switch off the transcription of multiple genes that encode inflammatory proteins</p>, <p>inhibit infiltration of airways by lymphocytes, eosinophils, mast cells; prevent LABA induced B receptor desensitization </p>, <p>iatrogenic cushing's syndrome; diabetes; growth retardation </p>, <p>oral thrush, hoarseness, cough </p>, <p>fluticasone, budesonide, mometasone, ciclesonide </p>, <p>prednisone, prednisolone </p>, <p>hydrocortiosne, prednisolone </p>, <p>leukotrienes </p>, <p>5-lipoxygenase; arachidonic acid </p>, <p>b</p>, <p>a,c</p>, <p>a</p>, <p>b</p>, <p>c</p>, <p>all leukotrienes </p>, <p>Arachidonic acid can go through two pathways; lipoxygenase or cycloxygenase; inhibiting COX-1 will shift the production to more leukotrienes</p>, <p>cromolyn, nedocromil </p>, <p>inhibit mast cell degranulation; preventing bronchospasms </p>, <p>allergic rhinoconjunctivitis </p>, <p>montelukast, zafirlukast, zileuton </p> flashcards
Pharmacology of Asthma (Anti-inflammatory drugs)

Pharmacology of Asthma (Anti-inflammatory drugs)

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  • switch off the transcription of multiple genes that encode inflammatory proteins

    Corticosteroids MOA?

  • inhibit infiltration of airways by lymphocytes, eosinophils, mast cells; prevent LABA induced B receptor desensitization

    What are the two most important functions of corticosteroids?

  • iatrogenic cushing's syndrome; diabetes; growth retardation

    Corticosteroids can cause _________. This can lead to _____ in adults and

    ______ in children.

  • oral thrush, hoarseness, cough

    What are the adverse effects of ICS? (3)

  • fluticasone, budesonide, mometasone, ciclesonide

    What are the ICS? (4)

  • prednisone, prednisolone

    What are the oral corticosteroids? (2)

  • hydrocortiosne, prednisolone

    What are the IV corticosteroids? (2)

  • leukotrienes

    - a signaling molecules that are chemotactic, promote bronchoconstriction

    and cause changes in vascular permeability

  • 5-lipoxygenase; arachidonic acid

    _________ oxidizes ________ to produce leukotrienes.

  • b

    Which has a BBW for causing neuropsychiatric disorders?

    a) zafirlukast

    b) montelukast

    c) zileuton

  • a,c

    Which can cause hepatotoxicity?

    a) zafirlukast

    b) montelukast

    c) zileuton

  • a

    Which is an LTD4 & LTE4 receptor antagonist?

    a) zafirlukast

    b) montelukast

    c) zileuton

  • b

    Which is only a LTD4 receptor antagonist?

    a) zafirlukast

    b) montelukast

    c) zileuton

  • c

    Which is a 5-LOX inhibitor?

    a) zafirlukast

    b) montelukast

    c) zileuton

  • all leukotrienes

    5-LOX inhibitors block the synthesis of ________.

  • Arachidonic acid can go through two pathways; lipoxygenase or cycloxygenase; inhibiting COX-1 will shift the production to more leukotrienes

    Why can using NSAIDs trigger asthma?

  • cromolyn, nedocromil

    What are our Mast-Cell stabilizers? (2)

  • inhibit mast cell degranulation; preventing bronchospasms

    Mast-cell stabilizer MOA?

  • allergic rhinoconjunctivitis

    What is the main use for Mast-cell stabilizers?

  • montelukast, zafirlukast, zileuton

    Which medications are targeted for leukotrienes? (3)