switch off the transcription of multiple genes that encode inflammatory proteins
Corticosteroids MOA?
inhibit infiltration of airways by lymphocytes, eosinophils, mast cells; prevent LABA induced B receptor desensitization
What are the two most important functions of corticosteroids?
iatrogenic cushing's syndrome; diabetes; growth retardation
Corticosteroids can cause _________. This can lead to _____ in adults and
______ in children.
oral thrush, hoarseness, cough
What are the adverse effects of ICS? (3)
fluticasone, budesonide, mometasone, ciclesonide
What are the ICS? (4)
prednisone, prednisolone
What are the oral corticosteroids? (2)
hydrocortiosne, prednisolone
What are the IV corticosteroids? (2)
leukotrienes
- a signaling molecules that are chemotactic, promote bronchoconstriction
and cause changes in vascular permeability
5-lipoxygenase; arachidonic acid
_________ oxidizes ________ to produce leukotrienes.
b
Which has a BBW for causing neuropsychiatric disorders?
a) zafirlukast
b) montelukast
c) zileuton
a,c
Which can cause hepatotoxicity?
a) zafirlukast
b) montelukast
c) zileuton
a
Which is an LTD4 & LTE4 receptor antagonist?
a) zafirlukast
b) montelukast
c) zileuton
b
Which is only a LTD4 receptor antagonist?
a) zafirlukast
b) montelukast
c) zileuton
c
Which is a 5-LOX inhibitor?
a) zafirlukast
b) montelukast
c) zileuton
all leukotrienes
5-LOX inhibitors block the synthesis of ________.
Arachidonic acid can go through two pathways; lipoxygenase or cycloxygenase; inhibiting COX-1 will shift the production to more leukotrienes
Why can using NSAIDs trigger asthma?
cromolyn, nedocromil
What are our Mast-Cell stabilizers? (2)
inhibit mast cell degranulation; preventing bronchospasms
Mast-cell stabilizer MOA?
allergic rhinoconjunctivitis
What is the main use for Mast-cell stabilizers?
montelukast, zafirlukast, zileuton
Which medications are targeted for leukotrienes? (3)