2023-09-09T23:12:27+03:00[Europe/Moscow] en true <p>- binds to <strong><span class="tt-bg-yellow">endogenous anti-thrombin</span></strong>; causing a conformational change. exposes active site for <strong><span class="tt-bg-yellow">rapid interaction with Factor Xa </span></strong>(without being consumed)</p>, <p>b,c</p>, <p>a</p>, <p>c</p>, <p>c</p>, <p>b</p>, <p>antithrombin; thrombin</p>, <p>c</p>, <p>longer DOA</p>, <p>a</p>, <p>protamine sulfate</p>, <p>too much can cause anticoagulation effect; must titrate</p>, <p>c</p>, <p>Direct thrombin inhibitors </p>, <p>argatroban, dabigatran, bivalirudin, </p>, <p>a,d</p>, <p>b,c</p>, <p>c</p>, <p>c</p>, <p>c</p>, <p>c</p>, <p>alteplase, reteplase, tenecteplase </p>, <p>heparin, LMWH, fondaparinux </p>, <p>dabigatran, rivaroxaban </p>, <p>bivalirudin</p>, <p>reversible/selective inhibitor that work on free &amp; clot-bound factor xa</p>, <p>directly inhibits thrombin, prevents fibrin mesh from being formed, and inhibits platelet activation. </p> flashcards
Pharmacology (Anticoagulation)

Pharmacology (Anticoagulation)

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  • - binds to endogenous anti-thrombin; causing a conformational change. exposes active site for rapid interaction with Factor Xa (without being consumed)

    Indirect Thrombin inhibitors MOA?

  • b,c

    Which have the same activity?

    a) Unfractionated Heparin (UF)

    b) LMW Heparin

    c) Fondaparinux

  • a

    Which potentiates inhibition of Factor Xa and thrombin?

    a) Unfractionated Heparin (UF)

    b) LMW Heparin

    c) Fondaparinux

  • c

    Which ONLY potentiates inhibition of Factor Xa?

    a) Unfractionated Heparin (UF)

    b) LMW Heparin

    c) Fondaparinux

  • c

    Which is only the pentasaccharide sequence?

    a) Unfractionated Heparin (UF)

    b) LMW Heparin

    c) Fondaparinux

  • b

    Which can't inhibit much of thrombin because it is too short?

    a) Unfractionated Heparin (UF)

    b) LMW Heparin

    c) Fondaparinux

  • antithrombin; thrombin

    To potentiate thrombin inhibition, heparin must simultaneously bind to _______ and _______.

  • c

    Which has the longest half-life?

    a) Unfractionated Heparin (UF)

    b) LMW Heparin

    c) Fondaparinux

  • longer DOA

    LMW Heparin has a _________ than Unfractionated Heparin.

  • a

    Which has a dose-dependent half-life?

    a) Unfractionated Heparin (UF)

    b) LMW Heparin

    c) Fondaparinux

  • protamine sulfate

    What is the reversal agent for heparin?

  • too much can cause anticoagulation effect; must titrate

    Protamine sulfate Counseling note?

  • c

    Protamine Sulfate will NOT reverse the activity of ______.

    a) Unfractionated Heparin (UF)

    b) LMW Heparin

    c) Fondaparinux

  • Direct thrombin inhibitors

    -bind directly to the active site of thrombin, inhibiting its downstream

    effects.

  • argatroban, dabigatran, bivalirudin,

    What are the Direct Thrombin inhibitors? (3)

  • a,d

    Which are monovalent; meaning they only bind at the active site?

    a) argatroban

    b) hirudin

    c) bivalirudin

    d) dabigatran

  • b,c

    Which are bivalent; they bind to the active site + substrate recognition site?

    a) argatroban

    b) hirudin

    c) bivalirudin

    d) dabigatran

  • c

    Which can also inhibit platelet activation?

    a) argatroban

    b) hirudin

    c) bivalirudin

    d) dabigatran

  • c

    Which has a short-half life?

    a) argatroban

    b) hirudin

    c) bivalirudin

    d) dabigatran

  • c

    Which is available via IV?

    a) argatroban

    b) hirudin

    c) bivalirudin

    d) dabigatran

  • c

    Which can be used on patients w/ ACS undergoing PCI?

    a) argatroban

    b) hirudin

    c) bivalirudin

    d) dabigatran

  • alteplase, reteplase, tenecteplase

    What are the Fibrinolytic drugs? (3)

  • heparin, LMWH, fondaparinux

    What are the indirect thrombin inhibitors? (3)

  • dabigatran, rivaroxaban

    What are the Oral Direct Factor Xa inhibitors? (DOACs) (2)

  • bivalirudin

    __________ is a Direct thrombin inhibitor.

  • reversible/selective inhibitor that work on free & clot-bound factor xa

    DOAC's MOA?

  • directly inhibits thrombin, prevents fibrin mesh from being formed, and inhibits platelet activation.

    Bivalirudin MOA?