- binds to endogenous anti-thrombin; causing a conformational change. exposes active site for rapid interaction with Factor Xa (without being consumed)
Indirect Thrombin inhibitors MOA?
b,c
Which have the same activity?
a) Unfractionated Heparin (UF)
b) LMW Heparin
c) Fondaparinux
a
Which potentiates inhibition of Factor Xa and thrombin?
a) Unfractionated Heparin (UF)
b) LMW Heparin
c) Fondaparinux
c
Which ONLY potentiates inhibition of Factor Xa?
a) Unfractionated Heparin (UF)
b) LMW Heparin
c) Fondaparinux
c
Which is only the pentasaccharide sequence?
a) Unfractionated Heparin (UF)
b) LMW Heparin
c) Fondaparinux
b
Which can't inhibit much of thrombin because it is too short?
a) Unfractionated Heparin (UF)
b) LMW Heparin
c) Fondaparinux
antithrombin; thrombin
To potentiate thrombin inhibition, heparin must simultaneously bind to _______ and _______.
c
Which has the longest half-life?
a) Unfractionated Heparin (UF)
b) LMW Heparin
c) Fondaparinux
longer DOA
LMW Heparin has a _________ than Unfractionated Heparin.
a
Which has a dose-dependent half-life?
a) Unfractionated Heparin (UF)
b) LMW Heparin
c) Fondaparinux
protamine sulfate
What is the reversal agent for heparin?
too much can cause anticoagulation effect; must titrate
Protamine sulfate Counseling note?
c
Protamine Sulfate will NOT reverse the activity of ______.
a) Unfractionated Heparin (UF)
b) LMW Heparin
c) Fondaparinux
Direct thrombin inhibitors
-bind directly to the active site of thrombin, inhibiting its downstream
effects.
argatroban, dabigatran, bivalirudin,
What are the Direct Thrombin inhibitors? (3)
a,d
Which are monovalent; meaning they only bind at the active site?
a) argatroban
b) hirudin
c) bivalirudin
d) dabigatran
b,c
Which are bivalent; they bind to the active site + substrate recognition site?
a) argatroban
b) hirudin
c) bivalirudin
d) dabigatran
c
Which can also inhibit platelet activation?
a) argatroban
b) hirudin
c) bivalirudin
d) dabigatran
c
Which has a short-half life?
a) argatroban
b) hirudin
c) bivalirudin
d) dabigatran
c
Which is available via IV?
a) argatroban
b) hirudin
c) bivalirudin
d) dabigatran
c
Which can be used on patients w/ ACS undergoing PCI?
a) argatroban
b) hirudin
c) bivalirudin
d) dabigatran
alteplase, reteplase, tenecteplase
What are the Fibrinolytic drugs? (3)
heparin, LMWH, fondaparinux
What are the indirect thrombin inhibitors? (3)
dabigatran, rivaroxaban
What are the Oral Direct Factor Xa inhibitors? (DOACs) (2)
bivalirudin
__________ is a Direct thrombin inhibitor.
reversible/selective inhibitor that work on free & clot-bound factor xa
DOAC's MOA?
directly inhibits thrombin, prevents fibrin mesh from being formed, and inhibits platelet activation.
Bivalirudin MOA?