2023-09-11T04:41:11+03:00[Europe/Moscow] en true <p>b</p>, <p>c</p>, <p>a, b</p>, <p>liver has a lot of nitrate reductase </p>, <p>c</p>, <p>longer DOA; ASCVD</p>, <p>a</p>, <p>diastolic tension, cardiac contractility, and cardiac work</p>, <p>ranolazine</p>, <p>d</p>, <p>wall tension; myocardial oxygen requirement </p>, <p>f; decrease preload and afterload</p>, <p>prodrugs</p>, <p>c</p>, <p>ALDH2</p> flashcards
Pharmacology (Angina)

Pharmacology (Angina)

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  • b

    Which has the longest half-life?

    a) nitroglycerin

    b) isosorbide dinitrate

    c) isosorbide mononitrate

    d) ranolazine

  • c

    Which doesn't undergo much first-pass metabolism i.e. has a high bioavailability?

    a) nitroglycerin

    b) isosorbide dinitrate

    c) isosorbide mononitrate

    d) ranolazine

  • a, b

    Which have the lowest bioavailability?

    a) nitroglycerin

    b) isosorbide dinitrate

    c) isosorbide mononitrate

    d) ranolazine

  • liver has a lot of nitrate reductase

    Why do NTG products have such a short DOA?

  • c

    Which has the slowest onset of action?

    a) nitroglycerin

    b) isosorbide dinitrate

    c) isosorbide mononitrate

    d) ranolazine

  • longer DOA; ASCVD

    Oral administration is good for _________ & more common in ________.

  • a

    Which has the worst tolerance issues?

    a) nitroglycerin

    b) isosorbide dinitrate

    c) isosorbide mononitrate

    d) ranolazine

  • diastolic tension, cardiac contractility, and cardiac work

    Ranolazine reduces _______, _________, and ________.

  • ranolazine

    -inhibits late sodium current channels.

  • d

    Which is metabolized by CYP3A4?

    a) nitroglycerin

    b) isosorbide dinitrate

    c) isosorbide mononitrate

    d) ranolazine

  • wall tension; myocardial oxygen requirement

    Nitrates decrease _____ & _______.

  • f; decrease preload and afterload

    Nitrates only lower afterload. T/F?

  • prodrugs

    All nitrates are considered _________.

  • c

    Which race may have issues metabolizing Nitrates?

    a) black

    b) caucasian

    c) Asian

    d) arab

  • ALDH2

    Nitroglycerin bioactivation includes involving ________.