b
Which has the longest half-life?
a) nitroglycerin
b) isosorbide dinitrate
c) isosorbide mononitrate
d) ranolazine
c
Which doesn't undergo much first-pass metabolism i.e. has a high bioavailability?
a) nitroglycerin
b) isosorbide dinitrate
c) isosorbide mononitrate
d) ranolazine
a, b
Which have the lowest bioavailability?
a) nitroglycerin
b) isosorbide dinitrate
c) isosorbide mononitrate
d) ranolazine
liver has a lot of nitrate reductase
Why do NTG products have such a short DOA?
c
Which has the slowest onset of action?
a) nitroglycerin
b) isosorbide dinitrate
c) isosorbide mononitrate
d) ranolazine
longer DOA; ASCVD
Oral administration is good for _________ & more common in ________.
a
Which has the worst tolerance issues?
a) nitroglycerin
b) isosorbide dinitrate
c) isosorbide mononitrate
d) ranolazine
diastolic tension, cardiac contractility, and cardiac work
Ranolazine reduces _______, _________, and ________.
ranolazine
-inhibits late sodium current channels.
d
Which is metabolized by CYP3A4?
a) nitroglycerin
b) isosorbide dinitrate
c) isosorbide mononitrate
d) ranolazine
wall tension; myocardial oxygen requirement
Nitrates decrease _____ & _______.
f; decrease preload and afterload
Nitrates only lower afterload. T/F?
prodrugs
All nitrates are considered _________.
c
Which race may have issues metabolizing Nitrates?
a) black
b) caucasian
c) Asian
d) arab
ALDH2
Nitroglycerin bioactivation includes involving ________.