2022-10-29T00:45:54+03:00[Europe/Moscow] en true <p>Precision medicine </p>, <p>Pharmacogenetics </p>, <p>Pharmacogenomics </p>, <p>Clinical Laboratory Improvement Amendments (CLIA)</p>, <p>Microarray assay</p>, <p>accuracy</p>, <p>precision</p>, <p>Sensitivity </p>, <p>sensitivity= true positives/ true positives+false negatives</p>, <p>Specificity </p>, <p>specificity= true negatives/ true negatives + false positives</p>, <p>positive predictive value</p>, <p>negative predictive value</p>, <p>microsatellites </p>, <p>&gt;5</p>, <p>linkage equilibrium</p>, <p>linkage dis-equilibrium </p> flashcards
PGx: Basic Concepts and Fundamentals

PGx: Basic Concepts and Fundamentals

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  • Precision medicine

    -any acre that is guided by individual patient characteristics, including genetic characteristics and other factors such as diet and lifestyle, that maximize treatment benefits while minimizing adverse effects and cost

  • Pharmacogenetics

    -the study of the relationship between variations in a single gene and variability

  • Pharmacogenomics

    -the study of the relationship between variations in a large collection of genes

  • Clinical Laboratory Improvement Amendments (CLIA)

    -Centers for Medicare and Medicaid services (CMS) regulates all laboratory testing through the ___________

  • Microarray assay

    -diagnostic tool to help determine whether an individual possesses a mutation for a particular disease

  • accuracy

    -how close a measurement is to the correct or accepted value of the quantity being measured

  • precision

    -how close a series of measurements are to one another

  • Sensitivity

    -the ability to detect disease among those known to have the disease

  • sensitivity= true positives/ true positives+false negatives

    Formula for sensitivity ?

  • Specificity

    -the ability to detect disease among those know to NOT have the disease

  • specificity= true negatives/ true negatives + false positives

    Formula for specificity ?

  • positive predictive value

    -probability that people with a positive (abnormal) test will develop the disease

  • negative predictive value

    -probability that people with a negative (normal) test will not develop the disease

  • microsatellites

    Repeats of <5 are called _______

  • >5

    how many repeats for minisatellites?

  • linkage equilibrium

    When the chromosome breaks during meiosis, and the alleles are far apart from each other is called __________

  • linkage dis-equilibrium

    When the chromosome breaks during meiosis, and the alleles are close to each other; causing an increase to be found in population. This is called _________