Hosam Mohamed-
inhibits transpeptidasae and other related enzymes that cross-link mucopeptides.
MOA?
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Gm + cidal; not used in staph
Spectrum?
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IV/IM or SC
Route of administration?
-
allergies, serum sickness, kidney failure
Adverse effects?
-
RTI, endocarditis, syphilis
Uses?
-
1st pass urine; 90% excreted
PK?
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administer with probenecid
How do we make Pen G last longer?
-
persons with penicillin allergy or cephalosporin allergy
Contraindications?
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procaine, benzathine, bicillin
What are our Pen G's?
-
b
Which penicillin can only be administered IM and never IV?
a) Penicillin G Benzathine
b) Penicillin G Procaine
c) Bicillin
d) Penicillin V
-
a
Which penicillin can be administered both orally and intramuscularly?
a) Penicillin G Benzathine
b) Penicillin G Procaine
c) Bicillin
d) Penicillin V
-
Bicillin
- combination of Procaine & Benzathine
-
contains an electron withdrawing sidechain that prevents catalytic intramolecular reaction; resulting in acid stability and oral bioavailability
Penicillin V chemistry? What makes this formulation special?
-
a
Which formulation has the longest duration?
a) Penicillin G Benzathine
b) Penicillin G Procaine
c) Bicillin
d) Penicillin V
-
b
Which formulation can cause an increase in bp?
a) Penicillin G Benzathine
b) Penicillin G Procaine
c) Bicillin
d) Penicillin V
-
d
Which penicillin is considered a "biosynthetic" & is in the oral form?
a) Penicillin G Benzathine
b) Penicillin G Procaine
c) Bicillin
d) Penicillin V
-
b
Which penicillin is used to treat syphilitic eye disease or strep?
a) Penicillin G Benzathine
b) Penicillin G Procaine
c) Bicillin
d) Penicillin V
-
gangrene; syphilis
Penicillin G is the drug of choice when treating what conditions?
