inhibits transpeptidasae and other related enzymes that cross-link mucopeptides.
MOA?
Gm + cidal; not used in staph
Spectrum?
IV/IM or SC
Route of administration?
allergies, serum sickness, kidney failure
Adverse effects?
RTI, endocarditis, syphilis
Uses?
1st pass urine; 90% excreted
PK?
administer with probenecid
How do we make Pen G last longer?
persons with penicillin allergy or cephalosporin allergy
Contraindications?
procaine, benzathine, bicillin
What are our Pen G's?
b
Which penicillin can only be administered IM and never IV?
a) Penicillin G Benzathine
b) Penicillin G Procaine
c) Bicillin
d) Penicillin V
a
Which penicillin can be administered both orally and intramuscularly?
a) Penicillin G Benzathine
b) Penicillin G Procaine
c) Bicillin
d) Penicillin V
Bicillin
- combination of Procaine & Benzathine
contains an electron withdrawing sidechain that prevents catalytic intramolecular reaction; resulting in acid stability and oral bioavailability
Penicillin V chemistry? What makes this formulation special?
a
Which formulation has the longest duration?
a) Penicillin G Benzathine
b) Penicillin G Procaine
c) Bicillin
d) Penicillin V
b
Which formulation can cause an increase in bp?
a) Penicillin G Benzathine
b) Penicillin G Procaine
c) Bicillin
d) Penicillin V
d
Which penicillin is considered a "biosynthetic" & is in the oral form?
a) Penicillin G Benzathine
b) Penicillin G Procaine
c) Bicillin
d) Penicillin V
b
Which penicillin is used to treat syphilitic eye disease or strep?
a) Penicillin G Benzathine
b) Penicillin G Procaine
c) Bicillin
d) Penicillin V
gangrene; syphilis
Penicillin G is the drug of choice when treating what conditions?