2023-10-04T05:10:33+03:00[Europe/Moscow] en true <p>smoking, a1-antitrypsin deficiency </p>, <p>loss of lung elasticity, abnormal enlargement of airspaces, hyperinflated lung</p>, <p>exertional dyspnea, right-sided HF, </p>, <p>chronic bronchitis </p>, <p>TP53; KRAS</p>, <p>P16</p>, <p>middle ear disease, lower respiratory illness, sudden infant death syndrome</p>, <p>nasal irritation, lung cancer, CHD, low birth weight</p>, <p>triglycerides; HDL</p>, <p>inflammation, atherogenesis, macro/microvascular neuropathy, oxidative stress, DNA damage</p> flashcards
Pathophysiology of Smoking

Pathophysiology of Smoking

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  • smoking, a1-antitrypsin deficiency

    What are the causes of COPD? (2)

  • loss of lung elasticity, abnormal enlargement of airspaces, hyperinflated lung

    Emphysema causes : (3) ?

  • exertional dyspnea, right-sided HF,

    What conditions can COPD lead to? (2)

  • chronic bronchitis

    -hyper secretion of mucus in large airways resulting in obstruction of smaller airways

  • TP53; KRAS

    Mutations in _____ gene & ______ pathway cause cell proliferation in lung cancer.

  • P16

    -tumor suppressor gene

  • middle ear disease, lower respiratory illness, sudden infant death syndrome

    Health consequences of 2nd hand smoke in children? (3)

  • nasal irritation, lung cancer, CHD, low birth weight

    Health consequences of 2nd hand smoke in adults? (4)

  • triglycerides; HDL

    Smoking can cause an increase in ________ & decrease in __________.

  • inflammation, atherogenesis, macro/microvascular neuropathy, oxidative stress, DNA damage

    What are the causal outcomes of smoking? (5)