2023-10-02T23:59:11+03:00[Europe/Moscow] en true <p>aspirin, beta blockers</p>, <p>IgE; mast</p>, <p>histamine, tryptase, leukotrienes, prostaglandins</p>, <p>bronchoconstriction, airway edema, airway hyper-responsiveness, airway remodeling </p>, <p>type I Fc3 </p>, <p>f; most, but not all</p>, <p>IgE</p>, <p>&gt;= 300 microliters of eosinophils </p>, <p>d</p>, <p>c</p>, <p>a</p>, <p>d</p>, <p>2</p>, <p>IL-4; plasma </p>, <p>b</p>, <p>a</p>, <p>c</p>, <p>d</p>, <p>b</p>, <p>a</p>, <p>c</p>, <p>e</p>, <p>Thymus and activated-regulated chemokines (TARCs); Macrophage-derived chemokines (MDCs)</p>, <p>chemokines</p>, <p>eotaxin </p>, <p>Leukotriene B4</p> flashcards
Patho pt.2

Patho pt.2

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  • aspirin, beta blockers

    What medications can cause asthma? (2)

  • IgE; mast

    Upon _______ dependent activation, _____ cells release several

    inflammatory proteins.

  • histamine, tryptase, leukotrienes, prostaglandins

    What pro-inflammatory molecules do Mast cells release? (4)

  • bronchoconstriction, airway edema, airway hyper-responsiveness, airway remodeling

    What are the pathophysiological events that occur in Asthma? (4)

  • type I Fc3

    Allergen activation occurs through high-affinity IgE _______ receptor.

  • f; most, but not all

    Increased numbers of eosinophils exist in all asthmatic patients. T/F?

  • IgE

    What is the biomarker for Allergic Asthma?

  • >= 300 microliters of eosinophils

    What is the biomarker for Eosinophilic Asthma?

  • d

    The key-antigen presenting cells in Asthma.

    a) macrophages

    b) monocytes

    c) neutrophils

    d) dendritic cells

  • c

    ________ are increased in the presence of smoking.

    a) macrophages

    b) monocytes

    c) neutrophils

    d) dendritic cells

  • a

    The most numerous cell type in the airways.

    a) macrophages

    b) monocytes

    c) neutrophils

    d) dendritic cells

  • d

    These cells stimulate TH2 cell production from naive T cells.

    a) macrophages

    b) monocytes

    c) neutrophils

    d) dendritic cells

  • 2

    How many IgE molecules are required to cause degranulation of Mast cells?

  • IL-4; plasma

    ______ activates B-cells, which differentiate into _______ cells.

  • b

    When stimulated, has an immediate reaction.

    a) eosinophil

    b) mast cell

    c) plasma cell

  • a

    When stimulated, has a delayed reaction.

    a) eosinophil

    b) mast cell

    c) plasma cell

  • c

    Produces a specific IgE.

    a) eosinophil

    b) mast cell

    c) plasma cell

  • d

    Needed for eosinophil differentiation & survival.

    a) IL-1B

    b) IL-4

    c) IL-3/13

    d) IL-5

    e) GM-CSF

  • b

    Required for TH2 cell differentiation.

    a) IL-1B

    b) IL-4

    c) IL-3/13

    d) IL-5

    e) GM-CSF

  • a

    Amplify the inflammatory response.

    a) IL-1B

    b) IL-4

    c) IL-3/13

    d) IL-5

    e) GM-CSF

  • c

    Important for IgE formation & mast cell priming/recruitment.

    a) IL-1B

    b) IL-4

    c) IL-3/13

    d) IL-5

    e) GM-CSF

  • e

    Prolongs eosinophil survival in airways.

    a) IL-1B

    b) IL-4

    c) IL-3/13

    d) IL-5

    e) GM-CSF

  • Thymus and activated-regulated chemokines (TARCs); Macrophage-derived chemokines (MDCs)

    _______ & ______ recruit TH2 cells.

  • chemokines

    -recruit inflammatory cells into airways

  • eotaxin

    -recruits eosinophils.

  • Leukotriene B4

    _________ recruits neutrophils.