aspirin, beta blockers
What medications can cause asthma? (2)
IgE; mast
Upon _______ dependent activation, _____ cells release several
inflammatory proteins.
histamine, tryptase, leukotrienes, prostaglandins
What pro-inflammatory molecules do Mast cells release? (4)
bronchoconstriction, airway edema, airway hyper-responsiveness, airway remodeling
What are the pathophysiological events that occur in Asthma? (4)
type I Fc3
Allergen activation occurs through high-affinity IgE _______ receptor.
f; most, but not all
Increased numbers of eosinophils exist in all asthmatic patients. T/F?
IgE
What is the biomarker for Allergic Asthma?
>= 300 microliters of eosinophils
What is the biomarker for Eosinophilic Asthma?
d
The key-antigen presenting cells in Asthma.
a) macrophages
b) monocytes
c) neutrophils
d) dendritic cells
c
________ are increased in the presence of smoking.
a) macrophages
b) monocytes
c) neutrophils
d) dendritic cells
a
The most numerous cell type in the airways.
a) macrophages
b) monocytes
c) neutrophils
d) dendritic cells
d
These cells stimulate TH2 cell production from naive T cells.
a) macrophages
b) monocytes
c) neutrophils
d) dendritic cells
2
How many IgE molecules are required to cause degranulation of Mast cells?
IL-4; plasma
______ activates B-cells, which differentiate into _______ cells.
b
When stimulated, has an immediate reaction.
a) eosinophil
b) mast cell
c) plasma cell
a
When stimulated, has a delayed reaction.
a) eosinophil
b) mast cell
c) plasma cell
c
Produces a specific IgE.
a) eosinophil
b) mast cell
c) plasma cell
d
Needed for eosinophil differentiation & survival.
a) IL-1B
b) IL-4
c) IL-3/13
d) IL-5
e) GM-CSF
b
Required for TH2 cell differentiation.
a) IL-1B
b) IL-4
c) IL-3/13
d) IL-5
e) GM-CSF
a
Amplify the inflammatory response.
a) IL-1B
b) IL-4
c) IL-3/13
d) IL-5
e) GM-CSF
c
Important for IgE formation & mast cell priming/recruitment.
a) IL-1B
b) IL-4
c) IL-3/13
d) IL-5
e) GM-CSF
e
Prolongs eosinophil survival in airways.
a) IL-1B
b) IL-4
c) IL-3/13
d) IL-5
e) GM-CSF
Thymus and activated-regulated chemokines (TARCs); Macrophage-derived chemokines (MDCs)
_______ & ______ recruit TH2 cells.
chemokines
-recruit inflammatory cells into airways
eotaxin
-recruits eosinophils.
Leukotriene B4
_________ recruits neutrophils.