2023-10-15T03:00:41+03:00[Europe/Moscow] en true <p>clarithromycin, azithromycin, rifabutin </p>, <p>prevent action of hydrophobic abs, allow cell to dehydrate w/out dying, allow cell to grow in macrophages and hide from immune system </p>, <p>inhibits the function of <strong><span class="tt-bg-yellow">AcpM acyl carrier protein</span></strong>; prevents <strong><span class="tt-bg-yellow">biosynthesis</span></strong> of <strong><span class="tt-bg-yellow">mycolic acids </span></strong>needed for <strong><span class="tt-bg-yellow">cell walls</span></strong></p>, <p>vitamin B6/pyridoxine; reduce risk of peripheral neuropathy </p>, <p>inhibits <strong><span class="tt-bg-yellow">mycolic acid biosynthesis</span></strong> by inhibiting <strong><span class="tt-bg-yellow">mycobacterial fatty acid synthase</span></strong></p>, <p>-inhibits <strong><span class="tt-bg-yellow">arabinosyl transferases</span></strong>; preventing <strong><span class="tt-bg-yellow">cell wall synthesis</span></strong></p>, <p>a</p>, <p>c</p>, <p>d</p>, <p>Aminosalicylic Acid </p>, <p>e</p>, <p>a</p>, <p>nephrotoxicity, ototoxicity, eosinophilia </p>, <p>Clofazimine </p>, <p>b</p>, <p>b</p>, <p>c, d</p>, <p>-inhibits <strong><span class="tt-bg-yellow">mycobacterial proton pump</span></strong> needed to produce <strong><span class="tt-bg-yellow">ATP</span></strong></p>, <p>-inhibits cell wall biosynthesis by <strong><span class="tt-bg-yellow">inhibiting the oxidation</span></strong> of <strong><span class="tt-bg-yellow">hydroxymycolate</span></strong> to <strong><span class="tt-bg-yellow">ketomycolate</span></strong></p>, <p>d</p> flashcards
Mycobacterium Drugs (Nagle)

Mycobacterium Drugs (Nagle)

Customize
collection saved
Share
Long Term Learning Spaced Repetition
Add to Long Term Learning Desk
Fast learning Repeat this set of flashcards
Preview Test Spell
Play
Match
Review

  • clarithromycin, azithromycin, rifabutin

    What are the 1st line treatments for MAC? (3)

  • prevent action of hydrophobic abs, allow cell to dehydrate w/out dying, allow cell to grow in macrophages and hide from immune system

    What are the functions of mycolic acid? (3)

  • inhibits the function of AcpM acyl carrier protein; prevents biosynthesis of mycolic acids needed for cell walls

    Isoniazid MOA?

  • vitamin B6/pyridoxine; reduce risk of peripheral neuropathy

    What must be given with Isoniazid?

    Why?

  • inhibits mycolic acid biosynthesis by inhibiting mycobacterial fatty acid synthase

    Pyrazinamide MOA?

  • -inhibits arabinosyl transferases; preventing cell wall synthesis

    Ethambutol MOA?

  • a

    High doses of this drug can cause optic neuritis.

    a) ethambutol

    b) isoniazid

    c) pyrazinamide

    d)aminosalicylic acid

  • c

    Which one is a protonophore?

    a) ethambutol

    b) isoniazid

    c) pyrazinamide

    d)aminosalicylic acid

  • d

    Which one has extremely high rates of GI irritation?

    a) ethambutol

    b) isoniazid

    c) pyrazinamide

    d)aminosalicylic acid

  • Aminosalicylic Acid

    - PABA analog- inhibits folate enzymes

  • e

    Which has a similar MOA to Isoniazid?

    a) Capreomycin

    b) Clofazimine

    c) Bedaquiline

    d) Pretomanid

    e) Ethionamide

  • a

    Which has a similar MOA to Aminoglycosides?

    a) Capreomycin

    b) Clofazimine

    c) Bedaquiline

    d) Pretomanid

    e) Ethionamide

  • nephrotoxicity, ototoxicity, eosinophilia

    AEs of Capreomycin? (3)

  • Clofazimine

    -binds to guanine bases of DNA & inhibits template function

    - increases phospholipase A2 activity so bacteria accumulate toxic levels of lysophospholipids

  • b

    Which one has high rates of GI pain?

    a) Capreomycin

    b) Clofazimine

    c) Bedaquiline

    d) Pretomanid

    e) Ethionamide

  • b

    Which one causes the skin to turn red/brown?

    a) Capreomycin

    b) Clofazimine

    c) Bedaquiline

    d) Pretomanid

    e) Ethionamide

  • c, d

    Which are used for drug-resistant TB?

    a) Capreomycin

    b) Clofazimine

    c) Bedaquiline

    d) Pretomanid

    e) Ethionamide

  • -inhibits mycobacterial proton pump needed to produce ATP

    Bedaquiline MOA?

  • -inhibits cell wall biosynthesis by inhibiting the oxidation of hydroxymycolate to ketomycolate

    Pretomanid MOA?

  • d

    Which can cause the poisoning of bacteria in anaerobic conditions?

    a) Capreomycin

    b) Clofazimine

    c) Bedaquiline

    d) Pretomanid

    e) Ethionamide