2023-12-03T23:08:20+03:00[Europe/Moscow] en true <p>L-tyrosine metabolized by tyrosine hydroxylase into L-Dopa; L-DOPA metabolized by LAAAD into DA; DA metabolized by dopamine hydroxylase into NE</p>, <p>b</p>, <p>a</p>, <p>homovanilic acid </p>, <p>antidepressants; PD drugs</p>, <p>c</p>, <p>a</p>, <p>a,b</p>, <p>propargylamine </p>, <p>a</p>, <p>c</p>, <p>nitrocatechol </p>, <p>b</p>, <p>b</p>, <p>false</p>, <p>a,c</p>, <p>a,d</p>, <p>a</p>, <p>b</p>, <p>d</p>, <p>b</p>, <p>d</p>, <p>CYP3A4</p>, <p>amino alcohol ether</p> flashcards
MedChem of PD drugs

MedChem of PD drugs

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  • L-tyrosine metabolized by tyrosine hydroxylase into L-Dopa; L-DOPA metabolized by LAAAD into DA; DA metabolized by dopamine hydroxylase into NE

    Describe the Biosynthesis of Dopamine ( In order). (3)

  • b

    When dopamine is metabolized by _____ it becomes 3-methoxytryamine.

    a) MAO

    b)COMT

  • a

    When dopamine is metabolized by _______ it becomes 3,4-dihydroxyphenylacetic acid.

    a) MAO

    b)COMT

  • homovanilic acid

    When DA is metabolized by MAO or COMT; it will end up as _________.

  • antidepressants; PD drugs

    MAO-A inhibitors are ________ and MAO-B inhibitors are __________.

  • c

    Which is the ONLY selective MAO-B inhibitor?

    a) selegiline

    b) rasagiline

    c) safinamide

  • a

    Which has amphetamine end-products when metabolized?

    a) selegiline

    b) rasagiline

    c) safinamide

  • a,b

    Which have significant drug-food interactions?

    a) selegiline

    b) rasagiline

    c) safinamide

  • propargylamine

    What is the principal pharmacophore of Selegiline/Rasagiline?

  • a

    Which is metabolized through N-dealkylation?

    a) selegiline

    b) rasagiline

    c) safinamide

  • c

    Which is metabolized by amidases?

    a) selegiline

    b) rasagiline

    c) safinamide

  • nitrocatechol

    What is the principal pharmacophore of COMT inhibitors?

  • b

    Which acts centrally AND peripherally?

    a) entacapone

    b) tolcapone

    c) opicapone

  • b

    Which has a BBW for fatal liver failure?

    a) entacapone

    b) tolcapone

    c) opicapone

  • false

    Amantadine does not cross the blood-brain-barrier. T/F?

  • a,c

    Which are D2 & D3 receptor agonists?

    a) Ropinirole

    b) Apomorphine

    c) Pramipexole

    d) Rotigotine

  • a,d

    Which is metabolized via N-dealkylation?

    a) Ropinirole

    b) Apomorphine

    c) Pramipexole

    d) Rotigotine

  • a

    Which has CYP1A2 interactions?

    a) Ropinirole

    b) Apomorphine

    c) Pramipexole

    d) Rotigotine

  • b

    Which is ONLY a D2 receptor agonist?

    a) Ropinirole

    b) Apomorphine

    c) Pramipexole

    d) Rotigotine

  • d

    Which is used as a transdermal patch?

    a) Ropinirole

    b) Apomorphine

    c) Pramipexole

    d) Rotigotine

  • b

    Which has contraindications with 5HT3 antagonists?

    a) Ropinirole

    b) Apomorphine

    c) Pramipexole

    d) Rotigotine

  • d

    Which undergoes extensive conjugation at the phenol?

    a) Ropinirole

    b) Apomorphine

    c) Pramipexole

    d) Rotigotine

  • CYP3A4

    Istradefylline is metabolized via _______.

  • amino alcohol ether

    Benztropine has an _________ structure.