L-tyrosine metabolized by tyrosine hydroxylase into L-Dopa; L-DOPA metabolized by LAAAD into DA; DA metabolized by dopamine hydroxylase into NE
Describe the Biosynthesis of Dopamine ( In order). (3)
b
When dopamine is metabolized by _____ it becomes 3-methoxytryamine.
a) MAO
b)COMT
a
When dopamine is metabolized by _______ it becomes 3,4-dihydroxyphenylacetic acid.
a) MAO
b)COMT
homovanilic acid
When DA is metabolized by MAO or COMT; it will end up as _________.
antidepressants; PD drugs
MAO-A inhibitors are ________ and MAO-B inhibitors are __________.
c
Which is the ONLY selective MAO-B inhibitor?
a) selegiline
b) rasagiline
c) safinamide
a
Which has amphetamine end-products when metabolized?
a) selegiline
b) rasagiline
c) safinamide
a,b
Which have significant drug-food interactions?
a) selegiline
b) rasagiline
c) safinamide
propargylamine
What is the principal pharmacophore of Selegiline/Rasagiline?
a
Which is metabolized through N-dealkylation?
a) selegiline
b) rasagiline
c) safinamide
c
Which is metabolized by amidases?
a) selegiline
b) rasagiline
c) safinamide
nitrocatechol
What is the principal pharmacophore of COMT inhibitors?
b
Which acts centrally AND peripherally?
a) entacapone
b) tolcapone
c) opicapone
b
Which has a BBW for fatal liver failure?
a) entacapone
b) tolcapone
c) opicapone
false
Amantadine does not cross the blood-brain-barrier. T/F?
a,c
Which are D2 & D3 receptor agonists?
a) Ropinirole
b) Apomorphine
c) Pramipexole
d) Rotigotine
a,d
Which is metabolized via N-dealkylation?
a) Ropinirole
b) Apomorphine
c) Pramipexole
d) Rotigotine
a
Which has CYP1A2 interactions?
a) Ropinirole
b) Apomorphine
c) Pramipexole
d) Rotigotine
b
Which is ONLY a D2 receptor agonist?
a) Ropinirole
b) Apomorphine
c) Pramipexole
d) Rotigotine
d
Which is used as a transdermal patch?
a) Ropinirole
b) Apomorphine
c) Pramipexole
d) Rotigotine
b
Which has contraindications with 5HT3 antagonists?
a) Ropinirole
b) Apomorphine
c) Pramipexole
d) Rotigotine
d
Which undergoes extensive conjugation at the phenol?
a) Ropinirole
b) Apomorphine
c) Pramipexole
d) Rotigotine
CYP3A4
Istradefylline is metabolized via _______.
amino alcohol ether
Benztropine has an _________ structure.