Hosam Mohamed-
c
Which has a sulfa group but NO sulfa allergy?
a) dofetilide
b) amiodarone
c) dronedarone
d) ibutilide
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a
Which has two sulfa groups w low sulfa allergy?
a) dofetilide
b) amiodarone
c) dronedarone
d) ibutilide
-
d
Which has a sulfa group WITH sulfa allergy?
a) dofetilide
b) amiodarone
c) dronedarone
d) ibutilide
-
amide group addition; longer half-life & more selectivity towards heart channels
What chemical substitution was done to Procainamide?
What does this do to its activity?
-
b,d
Which are racemic mixtures?
a) acebutolol
b) metoprolol
c) esmolol
d) propranolol
-
a
Which are metabolized into active drug?
a) acebutolol
b) metoprolol
c) esmolol
d) propranolol
-
c
Which one is metabolized fastest?
a) acebutolol
b) metoprolol
c) esmolol
d) propranolol
-
reversed amide & carbonyl groups; methyl groups on aromatic ring
Which chemical changes made Lidocaine a weak antiarrhythmic compared to Procainamide? (2)
-
one stereogenic center, equipotent, equal quantities
What are the qualities of Propafenones isomers? (3)
