c
Which has a sulfa group but NO sulfa allergy?
a) dofetilide
b) amiodarone
c) dronedarone
d) ibutilide
a
Which has two sulfa groups w low sulfa allergy?
a) dofetilide
b) amiodarone
c) dronedarone
d) ibutilide
d
Which has a sulfa group WITH sulfa allergy?
a) dofetilide
b) amiodarone
c) dronedarone
d) ibutilide
amide group addition; longer half-life & more selectivity towards heart channels
What chemical substitution was done to Procainamide?
What does this do to its activity?
b,d
Which are racemic mixtures?
a) acebutolol
b) metoprolol
c) esmolol
d) propranolol
a
Which are metabolized into active drug?
a) acebutolol
b) metoprolol
c) esmolol
d) propranolol
c
Which one is metabolized fastest?
a) acebutolol
b) metoprolol
c) esmolol
d) propranolol
reversed amide & carbonyl groups; methyl groups on aromatic ring
Which chemical changes made Lidocaine a weak antiarrhythmic compared to Procainamide? (2)
one stereogenic center, equipotent, equal quantities
What are the qualities of Propafenones isomers? (3)