Mechanisms of Action

inhibits cell wall synthesis by binding to the D-alanyl and D-alanine portion of cell wall precursor

inhibits DNA/RNA/Protein synthesis by binding to the cell membrane

inhibits DNA replication by binding to DNA gyrase (topoisomerase II) and topoisomerase IV.

inhibits dihydrofolic acid formation

inhibits dihydrofolic acid reduction to tetrahydrofolate

binds to the phospholipid bilayer altering cell permeability

reduction to reactive intermediate that inactivate/alter ribosomes and other macromolecules

forms free radicals inside the bacterial cytoplasm

inhibits bacterial cell wall synthesis via inactivation of enolpyruvyl transferase

inhibits cell wall synthesis by binding to penicillin binding proteins

Which ab's have two interior target sites? (3)