glycopeptides; lipoglycopeptides
inhibits cell wall synthesis by binding to the D-alanyl and D-alanine portion of cell wall precursor
lipopeptides
inhibits DNA/RNA/Protein synthesis by binding to the cell membrane
fluoroquinolones
inhibits DNA replication by binding to DNA gyrase (topoisomerase II) and topoisomerase IV.
sulfamethoxazole
inhibits dihydrofolic acid formation
trimethoprim
inhibits dihydrofolic acid reduction to tetrahydrofolate
polymyxin
binds to the phospholipid bilayer altering cell permeability
nitrofurans
reduction to reactive intermediate that inactivate/alter ribosomes and other macromolecules
nitroimidazoles
forms free radicals inside the bacterial cytoplasm
fosfomycin
inhibits bacterial cell wall synthesis via inactivation of enolpyruvyl transferase
monobactam
inhibits cell wall synthesis by binding to penicillin binding proteins
aminoglycosides, fluoroquinolones, bactrim
Which ab's have two interior target sites? (3)