2017-07-29T07:44:01+03:00[Europe/Moscow] en true Pomalidomide, Leflunomide, Natalizumab, Sirolimus, Fludarabine, Azathioprine, Immunosuppressive drug, Sodium aurothiomalate, Tacrolimus, Daclizumab, Infliximab, Etanercept, Anakinra, Pimecrolimus, Basiliximab, Thalidomide, Ciclosporin, 7,12-Dimethylbenz(a)anthracene, Teriflunomide, Everolimus, Hydroxychloroquine, Penicillamine, Methotrexate, Chloroquine, Fingolimod, Lenalidomide, Umirolimus, Voclosporin, Ridaforolimus, Afelimomab, Alefacept, Abatacept, 4-Deoxypyridoxine, Ascomycin, Pegsunercept, Gusperimus, Ponesimod, Eritoran, Secukinumab, Belimumab, Anti-thymocyte globulin, Adalimumab, Laquinimod, Certolizumab pegol, Gliotoxin, Muromonab-CD3, Efalizumab, Zotarolimus, Variecolol, Briakinumab, Mapracorat, Mizoribine, Rilonacept, Ixekizumab, Ustekinumab, Mycophenolic acid, Eculizumab, Tocilizumab, Disodium aurothiomalate, Abetimus flashcards Immunosuppressants
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  • Pomalidomide
    Pomalidomide (INN, codenamed CC-4047, also known as 3-amino-thalidomide, trade name Pomalyst in the U.S. and Imnovid in EU and Russia) is a derivative of thalidomide marketed by Celgene.
  • Leflunomide
    Leflunomide (original brand name Arava) is an immunosuppressive disease-modifying antirheumatic drug (DMARD), used in active moderate-to-severe rheumatoid arthritis and psoriatic arthritis.
  • Natalizumab
    Natalizumab is a humanized monoclonal antibody against the cell adhesion molecule α4-integrin.
  • Sirolimus
    Sirolimus (INN/USAN), also known as rapamycin, is a macrolide compound produced by the bacterium Streptomyces hygroscopicus that is used in medicine to prevent organ transplant rejection and to treat lymphangioleiomyomatosis.
  • Fludarabine
    Fludarabine or fludarabine phosphate (Fludara) is a chemotherapy drug used in the treatment of hematological malignancies (cancers of blood cells such as leukemias and lymphomas).
  • Azathioprine
    Azathioprine (AZA), also known by its brand name Imuran, is an immunosuppressive drug used in organ transplantation and autoimmune diseases and belongs to the chemical class of purine analogues.
  • Immunosuppressive drug
    Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system.
  • Sodium aurothiomalate
    Sodium aurothiomalate (INN, known in the United States as gold sodium thiomalate) is a gold compound that is used for its immunosuppressive anti-rheumatic effects.
  • Tacrolimus
    Tacrolimus (also FK-506 or fujimycin, trade names Prograf, Advagraf, Protopic) is an immunosuppressive drug used mainly after allogeneic organ transplant to lower the risk of organ rejection.
  • Daclizumab
    Daclizumab (trade name Zinbryta) is a therapeutic humanized monoclonal antibody used for the treatment of adults with relapsing forms of multiple sclerosis.
  • Infliximab
    Infliximab (trade names Remicade among others) is a chimeric monoclonal antibody biologic drug that works against tumor necrosis factor alpha (TNF-α) and is used to treat autoimmune diseases.
  • Etanercept
    Etanercept (trade name Enbrel) is a biopharmaceutical that treats autoimmune diseases by interfering with tumor necrosis factor (TNF; a soluble inflammatory cytokine) by acting as a TNF inhibitor.
  • Anakinra
    Anakinra (brand name Kineret) is a drug used to treat rheumatoid arthritis.
  • Pimecrolimus
    Pimecrolimus is an immunomodulating agent used in the treatment of atopic dermatitis (eczema).
  • Basiliximab
    Basiliximab (trade name Simulect) is a chimeric mouse-human monoclonal antibody to the α chain (CD25) of the IL-2 receptor of T cells.
  • Thalidomide
    Thalidomide sold under the brand names Immunoprin, among others, is an immunomodulatory drug and the prototype of the thalidomide class of drugs.
  • Ciclosporin
    Ciclosporin, also spelled cyclosporine, is an immunosuppressant drug widely used in organ transplantation to prevent rejection.
  • 7,12-Dimethylbenz(a)anthracene
    7,12-Dimethylbenz[a]anthracene (DMBA) is an immunosuppressor and a powerful organ-specific laboratory carcinogen.
  • Teriflunomide
    Teriflunomide (trade name Aubagio, marketed by Sanofi) is the active metabolite of leflunomide.
  • Everolimus
    Everolimus (INN) (/ˌɛvəˈroʊləməs/) (earlier code name RAD001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an inhibitor of mammalian target of rapamycin (mTOR).
  • Hydroxychloroquine
    Hydroxychloroquine (HCQ), sold under the trade names Plaquenil among others, is an antimalarial medication.
  • Penicillamine
    Penicillamine, sold under the trade names of Cuprimine, Cuprenyl and Depen, is a medication of the chelator class.
  • Methotrexate
    Methotrexate (MTX), formerly known as amethopterin, is a chemotherapy agent and immune system suppressant.
  • Chloroquine
    Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects.
  • Fingolimod
    Fingolimod (INN, trade name Gilenya, Novartis) is an immunomodulating drug, mostly used for treating multiple sclerosis (MS).
  • Lenalidomide
    Lenalidomide (trade name Revlimid) is a derivative of thalidomide introduced in 2004.
  • Umirolimus
    Umirolimus (INN/USAN), is a macrocyclic lactone, a highly lipophilic derivative of sirolimus, an immunosuppressant.
  • Voclosporin
    Voclosporin is an experimental immunosuppressant drug being developed by Isotechnika and Lux Biosciences.
  • Ridaforolimus
    Ridaforolimus (also known as AP23573 and MK-8669; formerly known as Deforolimus) is an investigational targeted and small-molecule inhibitor of the protein mTOR, a protein that acts as a central regulator of protein synthesis, cell proliferation, cell cycle progression and cell survival, integrating signals from proteins, such as PI3K, AKT and PTEN known to be important to malignancy.
  • Afelimomab
    Afelimomab (MAK 195F) is an anti-TNFα monoclonal antibody.
  • Alefacept
    Alefacept is a genetically engineered immunosuppressive drug.
  • Abatacept
    Abatacept (marketed as Orencia) is a drug used to treat autoimmune diseases like rheumatoid arthritis, by interfering with the immune activity of T cells.
  • 4-Deoxypyridoxine
    4-Deoxypyridoxine is a vitamin B6 antagonist.
  • Ascomycin
    Ascomycin, also called Immunomycin, FR-900520, FK520, is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties.
  • Pegsunercept
    Pegsunercept is a drug for the treatment of rheumatoid arthritis.
  • Gusperimus
    Gusperimus is an immunosuppressive drug.
  • Ponesimod
    Ponesimod (INN, codenamed ACT-128800) is an experimental drug for the treatment of multiple sclerosis (MS) and psoriasis.
  • Eritoran
    Eritoran is an investigational drug for the treatment of severe sepsis, an excessive inflammatory response to an infection.
  • Secukinumab
    Secukinumab, trade name Cosentyx, is a human monoclonal antibody that binds to the protein interleukin (IL)-17A,and is manufactured by Novartis Pharma AG for the treatment of psoriasis.
  • Belimumab
    Belimumab (trade name Benlysta, previously known as LymphoStat-B) is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), also known as B-lymphocyte stimulator (BLyS).
  • Anti-thymocyte globulin
    Anti-thymocyte globulin (ATG) is an infusion of horse or rabbit-derived antibodies against human T cells, which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia.
  • Adalimumab
    Adalimumab (trade names Humira and Exemptia) is a medication used for rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, moderate to severe chronic psoriasis, moderate to severe hidradenitis suppurativa, and juvenile idiopathic arthritis.
  • Laquinimod
    Laquinimod is an experimental immunomodulator developed by Active Biotech and Teva.
  • Certolizumab pegol
    Certolizumab pegol (CDP870, tradename Cimzia) is a biologic medication for the treatment of Crohn's disease, rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis.
  • Gliotoxin
    Gliotoxin is a sulfur-containing mycotoxin that belongs to a class of naturally occurring 2,5-diketopiperazines produced by several species of fungi, especially those of marine origin.
  • Muromonab-CD3
    Muromonab-CD3 (trade name Orthoclone OKT3, marketed by Janssen-Cilag) is an immunosuppressant drug given to reduce acute rejection in patients with organ transplants.
  • Efalizumab
    Efalizumab (trade name Raptiva, Genentech, Merck Serono) is a formerly available medication designed to treat autoimmune diseases, originally marketed to treat psoriasis.
  • Zotarolimus
    Zotarolimus (INN, codenamed ABT-578) is an immunosuppressant.
  • Variecolol
    Variecolol is an immunosuppressant/antiviral alkaloid isolated from ascomycete.
  • Briakinumab
    Briakinumab (ABT-874) is a human monoclonal antibody being developed by Abbott Laboratories for the treatment of rheumatoid arthritis, inflammatory bowel disease, and multiple sclerosis.
  • Mapracorat
    Mapracorat (INN, code names BOL-303242-X, ZK-245186) is an anti-inflammatory drug belonging to the experimental class of selective glucocorticoid receptor agonists (SEGRAs).
  • Mizoribine
    Mizoribine (INN, trade name Bredinin) is an immunosuppressive drug.
  • Rilonacept
    Rilonacept, also known as IL-1 Trap (marketed by Regeneron Pharmaceuticals under the trade name Arcalyst), is an interleukin 1 inhibitor.
  • Ixekizumab
    Ixekizumab (trade name Taltz) is an injectable drug for the treatment of autoimmune diseases.
  • Ustekinumab
    Ustekinumab (INN, experimental name CNTO 1275, proprietary commercial name Stelara, Centocor) is a human monoclonal antibody.
  • Mycophenolic acid
    Mycophenolic acid, less accurately called mycophenolate, is an immunosuppressant drug used to prevent rejection in organ transplantation.
  • Eculizumab
    Eculizumab (INN and USAN; trade name Soliris) is a humanized monoclonal antibody that is a terminal complement inhibitor.
  • Tocilizumab
    Tocilizumab (INN, or atlizumab, developed by Hoffmann–La Roche and Chugai and sold under the trade names Actemra and RoActemra) is an immunosuppressive drug, mainly for the treatment of rheumatoid arthritis (RA) and systemic juvenile idiopathic arthritis, a severe form of arthritis in children.
  • Disodium aurothiomalate
    Disodium aurothiomalate is a chemical compound with the formula AuSCH(CO2Na)CH2CO2Na.
  • Abetimus
    Abetimus is an immunosuppressant.