2017-07-31T01:40:21+03:00[Europe/Moscow] en true Ribonuclease inhibitor, Thelephoric acid, UK-414,495, Ecallantide, Rhc80267, Talopeptin, PUGNAc, Migalastat, GM6001, Lipstatin, Cilastatin, Batimastat, Phosphoramidon, Cipemastat, Thapsigargin, Ethyl protocatechuate, Marimastat, S-17092, Sivelestat flashcards
Hydrolase inhibitors

Hydrolase inhibitors

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  • Ribonuclease inhibitor
    Ribonuclease inhibitor (RI) is a large (~450 residues, ~49 kDa), acidic (pI ~4.7), leucine-rich repeat protein that forms extremely tight complexes with certain ribonucleases.
  • Thelephoric acid
    Thelephoric acid is a terphenylquinone pigment that is found in several fungi, such as Omphalotus subilludens and Polyozellus multiplex.
  • UK-414,495
    UK-414,495 is a drug developed by Pfizer for the treatment of female sexual arousal disorder.
  • Ecallantide
    Ecallantide (trade name Kalbitor, investigational name DX-88) is a drug used for the treatment of hereditary angioedema (HAE) and in the prevention of blood loss in cardiothoracic surgery.
  • Rhc80267
    RHC80267 is an inhibitor of diacylglycerol lipase.
  • Talopeptin
    Talopeptin is a chemical compound derived from cultures of Streptomyces.
  • PUGNAc
    PUGNAc is a 1,5-hydroximolactone, acting as an inhibitor of a variety of N-acetylhexosaminidases.
  • Migalastat
    Migalastat (INN/USAN, or 1-deoxygalactonojirimycin, trade name Galafold) is a drug for the treatment of Fabry disease, a rare genetic disorder.
  • GM6001
    GM6001 also known as galardin or ilomastat is a broad-spectrum matrix metalloproteinase inhibitor.
  • Lipstatin
    Lipstatin is a potent, irreversible inhibitor of pancreatic lipase.
  • Cilastatin
    Cilastatin is a chemical compound which inhibits the human enzyme dehydropeptidase.
  • Batimastat
    Batimastat (INN/USAN, codenamed BB-94) is an anticancer drug that belongs to the family of drugs called angiogenesis inhibitors.
  • Phosphoramidon
    Phosphoramidon is a chemical compound derived from cultures of Streptomyces tanashiensis.
  • Cipemastat
    Cipemastat (rINN, also known as Ro 32-3555 and by the tentative trade name Trocade) is a selective inhibitor of matrix metalloproteinase-1 that has been investigated as an anti-arthritis agent.
  • Thapsigargin
    Thapsigargin is non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA).
  • Ethyl protocatechuate
    Ethyl protocatechuate is a phenolic compound.
  • Marimastat
    Marimastat was a proposed antineoplastic drug developed by British Biotech.
  • S-17092
    S-17092 is a drug which acts as a selective inhibitor of the enzyme prolyl endopeptidase.
  • Sivelestat
    Sivelestat (INN, research name ONO 5046, marketed as Elaspol) is an inhibitor of human neutrophil elastase.