Hosam Mohamed-
hydralazine, minoxodil
What are our arterial dilators? (2)
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HTN, HF, angina
Which conditions are arterial dilators useful for? (3)
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reduce: PR, preload, O2 demand
How do arterial dilators affect BP=CO x PR?
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Edema, HF, angina
Which conditions are venous dilators useful for?
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nitrates
What are the venous dilators?
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a, c
Which mixed dilators affect the veins & arteries equally?
a) ACEis/ ARBS
b) CCBs
c) a2 agonists
d) a1 blockers
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b,d
Which mixed dilators affect the arteries slightly more?
a) ACEis/ ARBS
b) CCBs
c) a2 agonists
d) a1 blockers
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decrease preload & O2 demand
How do venous dilators affect BP= CO x PR?
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lupus, edema, reflex tachycardia
AE's of Hydralazine? (3)
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f; requires TID-QID dosing
Compliance issues are not a problem with Hydralazine. T/F?
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a
Fast acetylators have ______
a) decreased efficacy
b) more toxicity
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b
Slow acetylators have _____
a) decreased efficacy
b) more toxicity
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sulfonamiddes, hydralazine, isoniazid, procainamide
Which meds are affected by acetylation? (4)
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asian, inuit, jewish, egyptian
Which ethnic groups are slow acetylators? (4)
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a
Which is more potent?
a) minoxidil
b) hydralazine
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increased edema, tachycardia, hirsutism, pericardial effusion
AE's of Minoxidil? (4)
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resistant HTN w drug-induced lupus from hydralazine
Who is Minoxidil used for?
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a
Which is dosed 1-2x a day?
a) minoxidil
b) hydralazine
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a
Which one may require loop diuretics?
a) minoxidil
b) hydralazine
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b
Which one can be taken with food to improve absorption?
a) minoxidil
b) hydralazine
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severe CKD, AA w/ HFrEF, preeclampsia
What is Hydralazine useful for? (3)
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thiazide
How do we treat Hydralazine-induced lupus?
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BB or non-DHP
How do we treat Hydralazine-induced reflex tachycardia?
