hydralazine, minoxodil
What are our arterial dilators? (2)
HTN, HF, angina
Which conditions are arterial dilators useful for? (3)
reduce: PR, preload, O2 demand
How do arterial dilators affect BP=CO x PR?
Edema, HF, angina
Which conditions are venous dilators useful for?
nitrates
What are the venous dilators?
a, c
Which mixed dilators affect the veins & arteries equally?
a) ACEis/ ARBS
b) CCBs
c) a2 agonists
d) a1 blockers
b,d
Which mixed dilators affect the arteries slightly more?
a) ACEis/ ARBS
b) CCBs
c) a2 agonists
d) a1 blockers
decrease preload & O2 demand
How do venous dilators affect BP= CO x PR?
lupus, edema, reflex tachycardia
AE's of Hydralazine? (3)
f; requires TID-QID dosing
Compliance issues are not a problem with Hydralazine. T/F?
a
Fast acetylators have ______
a) decreased efficacy
b) more toxicity
b
Slow acetylators have _____
a) decreased efficacy
b) more toxicity
sulfonamiddes, hydralazine, isoniazid, procainamide
Which meds are affected by acetylation? (4)
asian, inuit, jewish, egyptian
Which ethnic groups are slow acetylators? (4)
a
Which is more potent?
a) minoxidil
b) hydralazine
increased edema, tachycardia, hirsutism, pericardial effusion
AE's of Minoxidil? (4)
resistant HTN w drug-induced lupus from hydralazine
Who is Minoxidil used for?
a
Which is dosed 1-2x a day?
a) minoxidil
b) hydralazine
a
Which one may require loop diuretics?
a) minoxidil
b) hydralazine
b
Which one can be taken with food to improve absorption?
a) minoxidil
b) hydralazine
severe CKD, AA w/ HFrEF, preeclampsia
What is Hydralazine useful for? (3)
thiazide
How do we treat Hydralazine-induced lupus?
BB or non-DHP
How do we treat Hydralazine-induced reflex tachycardia?