Hosam Mohamed-
b
Which is more balanced in regards to its effects on the heart & vasculature?
a) Verapamil
b) Dilitazem
-
stable ischemic heart disease, diabetics (2nd line)
CCB are best used for? (2)
-
a, c
Which diseases are treated with DHPs?
a) isolate systolic hypertension
b) supraventricular tachycardia
c) Raynaud's phenomenon
d) Migraine prophylaxis
-
b
Which diseases are treated with non-DHPs?
a) isolate systolic hypertension
b) supraventricular tachycardia
c) Raynaud's phenomenon
d) Migraine prophylaxis
-
c
Which is treated with Dilitazem?
a) isolate systolic hypertension
b) supraventricular tachycardia
c) Raynaud's phenomenon
d) Migraine prophylaxis
-
d
Which is treated with Verapamil?
a) isolate systolic hypertension
b) supraventricular tachycardia
c) Raynaud's phenomenon
d) Migraine prophylaxis
-
complete heart block, HFrEF
Who should we avoid/use cautiously when using CCBs? (2)
-
CYP3A4
Diltiazem and verapamil are metabolized by ______ enzymes.
-
b,c
Which drugs used with non-DHPs can result in bradycardia/heart block?
a) Grapefruit juice
b) beta blockers
c) a2 agonist
d) simvastatin
-
d
Which drugs used with non-DHPs can result in statin toxicity?
a) Grapefruit juice
b) beta blockers
c) a2 agonist
d) simvastatin
-
a
Which drugs used with non-DHPs can result in an increased anti-HTN response?
a) grapefruit juice
b) beta blockers
c) a2 agonist
d) simvastatin
-
f; contain different release mechanisms & bioavailability
Different Diltiazem products are interchangeable. T/F?
-
e
Which Diltiazem product is safe to split?
a) Generic ER (12-hour)
b) Generic ER (24-hour)
c) Cardizem
d) Cardia XT
e) Taxtia XT, Tiazac
-
c
Which Verapamil product is NOT safe to split?
a) Calan
b) Verelan
c) Covera HS
-
b
CCBs are all metabolized through the _____.
a) kidneys
b) liver
-
a
Which is NOT ER? (Long half-life)
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
-
a,b
Which is best if it has to be used in patients with HFrEF?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
-
a
Which is the only one that can be split or crushed?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
-
b
Which should be taken with a small, low fat/carb meal?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
-
c
Which is the ONLY one that is taken twice daily?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
-
d,e
Which are required to be taken on an empty stomach?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
-
e
Which has an Osmotic-control Release system?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
-
e
Which one may appear in a patient's stool after taking it?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
-
peripheral edema, gingival hyperplasia, depression, flushing, tachycardia, GI
CCB Adverse Effects? (6)
-
use ER/SR forms due to half-lives, take w food to help absorption, more DI's than DHPs
PK of non-DHPS?
-
a
Which has worse DIs?
a) verapamil
b) diltiazem
-
a
Which is the least affected by Grapefruit Juice?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
-
a
Statin dosing limits ONLY apply to ____.
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
