b
Which is more balanced in regards to its effects on the heart & vasculature?
a) Verapamil
b) Dilitazem
stable ischemic heart disease, diabetics (2nd line)
CCB are best used for? (2)
a, c
Which diseases are treated with DHPs?
a) isolate systolic hypertension
b) supraventricular tachycardia
c) Raynaud's phenomenon
d) Migraine prophylaxis
b
Which diseases are treated with non-DHPs?
a) isolate systolic hypertension
b) supraventricular tachycardia
c) Raynaud's phenomenon
d) Migraine prophylaxis
c
Which is treated with Dilitazem?
a) isolate systolic hypertension
b) supraventricular tachycardia
c) Raynaud's phenomenon
d) Migraine prophylaxis
d
Which is treated with Verapamil?
a) isolate systolic hypertension
b) supraventricular tachycardia
c) Raynaud's phenomenon
d) Migraine prophylaxis
complete heart block, HFrEF
Who should we avoid/use cautiously when using CCBs? (2)
CYP3A4
Diltiazem and verapamil are metabolized by ______ enzymes.
b,c
Which drugs used with non-DHPs can result in bradycardia/heart block?
a) Grapefruit juice
b) beta blockers
c) a2 agonist
d) simvastatin
d
Which drugs used with non-DHPs can result in statin toxicity?
a) Grapefruit juice
b) beta blockers
c) a2 agonist
d) simvastatin
a
Which drugs used with non-DHPs can result in an increased anti-HTN response?
a) grapefruit juice
b) beta blockers
c) a2 agonist
d) simvastatin
f; contain different release mechanisms & bioavailability
Different Diltiazem products are interchangeable. T/F?
e
Which Diltiazem product is safe to split?
a) Generic ER (12-hour)
b) Generic ER (24-hour)
c) Cardizem
d) Cardia XT
e) Taxtia XT, Tiazac
c
Which Verapamil product is NOT safe to split?
a) Calan
b) Verelan
c) Covera HS
b
CCBs are all metabolized through the _____.
a) kidneys
b) liver
a
Which is NOT ER? (Long half-life)
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
a,b
Which is best if it has to be used in patients with HFrEF?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
a
Which is the only one that can be split or crushed?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
b
Which should be taken with a small, low fat/carb meal?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
c
Which is the ONLY one that is taken twice daily?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
d,e
Which are required to be taken on an empty stomach?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
e
Which has an Osmotic-control Release system?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
e
Which one may appear in a patient's stool after taking it?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
peripheral edema, gingival hyperplasia, depression, flushing, tachycardia, GI
CCB Adverse Effects? (6)
use ER/SR forms due to half-lives, take w food to help absorption, more DI's than DHPs
PK of non-DHPS?
a
Which has worse DIs?
a) verapamil
b) diltiazem
a
Which is the least affected by Grapefruit Juice?
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine
a
Statin dosing limits ONLY apply to ____.
a) amlodipine
b) Felodipine
c) Isradipine
d) Nisoldipine
e) Nifedipine