2023-03-12T23:03:44+03:00[Europe/Moscow] en true <p>vancomycin, bacitracin </p>, <p>red man syndrome</p>, <p>narrow gm +; too polar for gm - membrane, too large for porin channels</p>, <p>d</p>, <p>d</p>, <p>oritavancin, dalbavancin, telavancin</p>, <p>b, c </p>, <p>b</p>, <p>b</p>, <p>b</p>, <p>c</p>, <p>telavancin, oritavancin phosphate, dalbavancin</p>, <p>e</p>, <p>keep patients hydrated</p>, <p>slow iv infusion with antihistamines </p>, <p>c</p>, <p>vancomycin</p>, <p>bacitracin </p>, <p>IM &amp; topical ointment</p>, <p>a</p>, <p>bacitracin; depends on dose</p>, <p>a</p>, <p>a</p>, <p>can cause nephrotoxicity </p>, <p>d</p>, <p>inhibits polymerization &amp; transglycose reaction A; achieves this by binding to d-ala-d-ala terminus; blocks linkage to glycopolypeptide polymers</p>, <p>NAM-NAG</p>, <p>inhibiting some protein synthesis</p>, <p>contain cell wall components that allow for it to act like detergents </p>, <p>inhibits cell wall synthesis by blocking phospholipid carrier cycle</p>, <p>blocks dephosphorylating step that releases NAG-NAM bound peptide precursors that form the growing peptidoglycan polymer</p>, <p>polymyxin B; neomycin</p>, <p>iv; vancomycin</p>, <p>oral, iv</p>, <p>PMC (c.diff), MRSA, entero faecalis </p>, <p>MRSA; complicated skin infection</p> flashcards
Glycopeptides, Lipoglycopeptides, and Polypeptide Agents

Glycopeptides, Lipoglycopeptides, and Polypeptide Agents

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  • vancomycin, bacitracin

    Which Glycopeptides are derived from natural products?

  • red man syndrome

    -side effect that causes for rapid histamine release into blood stream that causes face and back to turn red

    -if not treated; can lead to seizures and myocardial infarction

  • narrow gm +; too polar for gm - membrane, too large for porin channels

    What is the spectrum for Vancomycin? Why?

  • d

    Which cell wall agent) is 1st line treatment for PMC/C.diff?

    a) Bacitracin

    b) Oritavancin Phosphate

    c) Dalbavancin

    d) Vancomycin

    e) Telavancin

  • d

    Which cell wall agent can cause ototoxicity if given with an aminoglycoside?

    a) Bacitracin

    b) Oritavancin Phosphate

    c) Dalbavancin

    d) Vancomycin

    e) Telavancin

  • oritavancin, dalbavancin, telavancin

    Which cell wall agents possess a lipophilic side-chain?

  • b, c

    Which cell wall agent are good for outpatient therapy because of a long t 1/2?

    a) Bacitracin

    b) Oritavancin Phosphate

    c) Dalbavancin

    d) Vancomycin

    e) Telavancin

  • b

    Which cell wall agent is most active against C.diff?

    a) Bacitracin

    b) Oritavancin Phosphate

    c) Dalbavancin

    d) Vancomycin

    e) Telavancin

  • b

    Which cell wall agent has a side effect that can give a false positive clotting time?

    a) Bacitracin

    b) Oritavancin Phosphate

    c) Dalbavancin

    d) Vancomycin

    e) Telavancin

  • b

    Which cell wall agent has Heparin contraindication?

    a) Bacitracin

    b) Oritavancin Phosphate

    c) Dalbavancin

    d) Vancomycin

    e) Telavancin

  • c

    Which cell wall agent is semi-synthetic?

    a) Bacitracin

    b) Oritavancin Phosphate

    c) Dalbavancin

    d) Vancomycin

    e) Telavancin

  • telavancin, oritavancin phosphate, dalbavancin

    What are our Lipoglycopeptides?

  • e

    Which cell wall agent can cause an increased QT interval and interferes with clotting time?

    a) Bacitracin

    b) Oritavancin Phosphate

    c) Dalbavancin

    d) Vancomycin

    e) Telavancin

  • keep patients hydrated

    How do we treat/avoid nephrotoxicity in patients on Vancomycin?

  • slow iv infusion with antihistamines

    How do we administer Vancomycin?

  • c

    Which cell wall agent has been shown to NOT cause red-man syndrome?

    a) Bacitracin

    b) Oritavancin Phosphate

    c) Dalbavancin

    d) Vancomycin

    e) Telavancin

  • vancomycin

    What are our glycopeptides?

  • bacitracin

    What is our only Polypeptide cell wall inhibitor?

  • IM & topical ointment

    What are the dosage forms of Bacitracin?

  • a

    Which cell wall agent is used to for sterilization of wounds?

    a) Bacitracin

    b) Oritavancin Phosphate

    c) Dalbavancin

    d) Vancomycin

    e) Telavancin

  • bacitracin; depends on dose

    Which glycopeptide is considered to be either cidal or static? Why?

  • a

    Which cell wall agent can cause allergic dermatitis?

    a) Bacitracin

    b) Oritavancin Phosphate

    c) Dalbavancin

    d) Vancomycin

    e) Telavancin

  • a

    Which cell wall agent is a last resort therapy for highly resistant Gm (+) infections?

    a) Bacitracin

    b) Oritavancin Phosphate

    c) Dalbavancin

    d) Vancomycin

    e) Telavancin

  • can cause nephrotoxicity

    Why do we avoid dosing Bacitracin internally?

  • d

    Which cell wall agent is administered with Rifampin ?

    a) Bacitracin

    b) Oritavancin Phosphate

    c) Dalbavancin

    d) Vancomycin

    e) Telavancin

  • inhibits polymerization & transglycose reaction A; achieves this by binding to d-ala-d-ala terminus; blocks linkage to glycopolypeptide polymers

    What is the MOA of Glycopeptides?

  • NAM-NAG

    What are the specific Glycopolypeptide polymers that our glycopeptides bind to?

  • inhibiting some protein synthesis

    Besides inhibiting cell wall synthesis, glycopeptides can also be effective against bacteria by ________.

  • contain cell wall components that allow for it to act like detergents

    What is special about our Lipoglycopeptides?

  • inhibits cell wall synthesis by blocking phospholipid carrier cycle

    What is the MOA of Bacitracin?

  • blocks dephosphorylating step that releases NAG-NAM bound peptide precursors that form the growing peptidoglycan polymer

    What is another feature of Bacitracin's MOA that deals with Lipid II?

  • polymyxin B; neomycin

    OTC products that contain Bacitracin also add _______ & ________ to deal with Gm (-) activity.

  • iv; vancomycin

    Glycopeptides are all available _______ except for ________.

  • oral, iv

    What are the dosage forms for vancomycin?

  • PMC (c.diff), MRSA, entero faecalis

    Vancomycin tx?

  • MRSA; complicated skin infection

    Telavancin tx?