vancomycin, bacitracin
Which Glycopeptides are derived from natural products?
red man syndrome
-side effect that causes for rapid histamine release into blood stream that causes face and back to turn red
-if not treated; can lead to seizures and myocardial infarction
narrow gm +; too polar for gm - membrane, too large for porin channels
What is the spectrum for Vancomycin? Why?
d
Which cell wall agent) is 1st line treatment for PMC/C.diff?
a) Bacitracin
b) Oritavancin Phosphate
c) Dalbavancin
d) Vancomycin
e) Telavancin
d
Which cell wall agent can cause ototoxicity if given with an aminoglycoside?
a) Bacitracin
b) Oritavancin Phosphate
c) Dalbavancin
d) Vancomycin
e) Telavancin
oritavancin, dalbavancin, telavancin
Which cell wall agents possess a lipophilic side-chain?
b, c
Which cell wall agent are good for outpatient therapy because of a long t 1/2?
a) Bacitracin
b) Oritavancin Phosphate
c) Dalbavancin
d) Vancomycin
e) Telavancin
b
Which cell wall agent is most active against C.diff?
a) Bacitracin
b) Oritavancin Phosphate
c) Dalbavancin
d) Vancomycin
e) Telavancin
b
Which cell wall agent has a side effect that can give a false positive clotting time?
a) Bacitracin
b) Oritavancin Phosphate
c) Dalbavancin
d) Vancomycin
e) Telavancin
b
Which cell wall agent has Heparin contraindication?
a) Bacitracin
b) Oritavancin Phosphate
c) Dalbavancin
d) Vancomycin
e) Telavancin
c
Which cell wall agent is semi-synthetic?
a) Bacitracin
b) Oritavancin Phosphate
c) Dalbavancin
d) Vancomycin
e) Telavancin
telavancin, oritavancin phosphate, dalbavancin
What are our Lipoglycopeptides?
e
Which cell wall agent can cause an increased QT interval and interferes with clotting time?
a) Bacitracin
b) Oritavancin Phosphate
c) Dalbavancin
d) Vancomycin
e) Telavancin
keep patients hydrated
How do we treat/avoid nephrotoxicity in patients on Vancomycin?
slow iv infusion with antihistamines
How do we administer Vancomycin?
c
Which cell wall agent has been shown to NOT cause red-man syndrome?
a) Bacitracin
b) Oritavancin Phosphate
c) Dalbavancin
d) Vancomycin
e) Telavancin
vancomycin
What are our glycopeptides?
bacitracin
What is our only Polypeptide cell wall inhibitor?
IM & topical ointment
What are the dosage forms of Bacitracin?
a
Which cell wall agent is used to for sterilization of wounds?
a) Bacitracin
b) Oritavancin Phosphate
c) Dalbavancin
d) Vancomycin
e) Telavancin
bacitracin; depends on dose
Which glycopeptide is considered to be either cidal or static? Why?
a
Which cell wall agent can cause allergic dermatitis?
a) Bacitracin
b) Oritavancin Phosphate
c) Dalbavancin
d) Vancomycin
e) Telavancin
a
Which cell wall agent is a last resort therapy for highly resistant Gm (+) infections?
a) Bacitracin
b) Oritavancin Phosphate
c) Dalbavancin
d) Vancomycin
e) Telavancin
can cause nephrotoxicity
Why do we avoid dosing Bacitracin internally?
d
Which cell wall agent is administered with Rifampin ?
a) Bacitracin
b) Oritavancin Phosphate
c) Dalbavancin
d) Vancomycin
e) Telavancin
inhibits polymerization & transglycose reaction A; achieves this by binding to d-ala-d-ala terminus; blocks linkage to glycopolypeptide polymers
What is the MOA of Glycopeptides?
NAM-NAG
What are the specific Glycopolypeptide polymers that our glycopeptides bind to?
inhibiting some protein synthesis
Besides inhibiting cell wall synthesis, glycopeptides can also be effective against bacteria by ________.
contain cell wall components that allow for it to act like detergents
What is special about our Lipoglycopeptides?
inhibits cell wall synthesis by blocking phospholipid carrier cycle
What is the MOA of Bacitracin?
blocks dephosphorylating step that releases NAG-NAM bound peptide precursors that form the growing peptidoglycan polymer
What is another feature of Bacitracin's MOA that deals with Lipid II?
polymyxin B; neomycin
OTC products that contain Bacitracin also add _______ & ________ to deal with Gm (-) activity.
iv; vancomycin
Glycopeptides are all available _______ except for ________.
oral, iv
What are the dosage forms for vancomycin?
PMC (c.diff), MRSA, entero faecalis
Vancomycin tx?
MRSA; complicated skin infection
Telavancin tx?