2022-10-31T03:34:42+03:00[Europe/Moscow] en true <p>xN</p>, <p>metabolize it too fast; resulting in morphine overdose </p>, <p>decreased efficacy; won't be converted to morphine </p>, <p>SSRI or SNRI</p>, <p>Serotonin MOA</p>, <p>active</p>, <p>CYP2D6, CYP2C19</p>, <p>CYP2D6</p>, <p>select alternative drug not metabolized by CYP2D6</p>, <p>lower starting dose by 50% or select different drug</p>, <p>SSRI</p>, <p>SNRI</p>, <p>CYP2C19*2; CYP2C19*3</p>, <p>CYP2C19*17</p>, <p>ultrarapid metabolizer</p>, <p>poor metabolizer</p>, <p>Escitalopram (LEXAPRO)</p>, <p>OCD, chronic pain, migraine prophylaxis </p>, <p>serotonin system</p>, <p>norepinephrine system</p>, <p>B; lacks an alkyl group</p>, <p>serotonin system; tertiary amine</p>, <p>norepinephrine system; secondary amine</p>, <p>Phenoconversion </p>, <p>Risk evaluation mitigation strategy; clozapine </p>, <p>pseudo-parkinsons; blocking too much</p>, <p>d</p>, <p>CYP1A2</p>, <p>Patients with A/A may require larger dose</p>, <p>CYP2B6</p> flashcards
Genetic Variation and Drug Metabolism (Tschumper)

Genetic Variation and Drug Metabolism (Tschumper)

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  • xN

    Gene duplications and multiplications are denoted with a _______

  • metabolize it too fast; resulting in morphine overdose

    What effect will UM have on prodrugs like codeine?

  • decreased efficacy; won't be converted to morphine

    What effect will PM have on prodrug like codeine?

  • SSRI or SNRI

    What are the gold standard treatments for major depressive disorder?

  • Serotonin MOA

    block serotonin reuptake via SLC6A4 transporter; preventing reuptake into presynaptic neurons

  • active

    All SSRI are ________ parent drugs.

  • CYP2D6, CYP2C19

    Patients may be predisposed to poor therapeutic outcomes when taking SSRIs due to ________ or __________ polymorphisms.

  • CYP2D6

    Paroxetine is metabolized which enzyme?

  • select alternative drug not metabolized by CYP2D6

    What is the therapeutic recommendation for a UM in regards to Paroxetine & Atomoxetine ?

  • lower starting dose by 50% or select different drug

    What is the therapeutic recommendation for a PM in regards to Paroxetine & Atomoxetine?

  • SSRI

    What is pharmacological class of Paroxetine?

  • SNRI

    What is the pharmacological class of Atomoxetine (Strattera)?

  • CYP2C19*2; CYP2C19*3

    What is the nomenclature for inactive CYP2C19 enzymes?

  • CYP2C19*17

    What is the nomenclature for increased function CYP2C19 enzymes?

  • ultrarapid metabolizer

    What is the phenotype of someone who has *1/*17?

  • poor metabolizer

    What is the phenotype of someone who has *2/*3?

  • Escitalopram (LEXAPRO)

    - is the S-enantiomer

    -an active compound

    - metabolized by CYP2C19

  • OCD, chronic pain, migraine prophylaxis

    Tricyclic Antidepressants are used to treat depression but are also used for_______

  • serotonin system

    "3" or tertiary amine side chain has a greater impact on the _______

  • norepinephrine system

    "2" or secondary amine side chain has a greater impact on the ______

  • B; lacks an alkyl group

    A refers to the drug on the left; B refers to the drug on the right.Which one is norepinephrine? How do you know?

    A refers to the drug on the left; B refers to the drug on the right.

    Which one is norepinephrine? How do you know?

  • serotonin system; tertiary amine

    This drug will exert its best effect on _______. How do you know this?

    This drug will exert its best effect on _______. How do you know this?

  • norepinephrine system; secondary amine

    This drug will exert its best effect on _______. How do you know this?

    This drug will exert its best effect on _______. How do you know this?

  • Phenoconversion

    -genetically mediated metabolic activity is converted to a different metabolic activity phenotype due to an intrinsic factor; usually from drug-drug interactions

  • Risk evaluation mitigation strategy; clozapine

    Patients and providers must be registered in the __________ when _________ is prescribed.

  • pseudo-parkinsons; blocking too much

    1st gen or typical antipsychotics can cause __________ from __________ dopamine.

  • d

    Clozapine reduces what type of leukocyte?

    a. eosinophils

    b. macrophages

    c. basophils

    d. neutrophils

  • CYP1A2

    Clozapine is primarily metabolized by _____

  • Patients with A/A may require larger dose

    A single nucleotide polymorphism of CYP1A2 suggests that the A/A genotype was more inducible than the C/A or C/C genotypes. What does this mean for prescribers?

  • CYP2B6

    What is the enzyme responsible for metabolizing Buproprion?