xN
Gene duplications and multiplications are denoted with a _______
metabolize it too fast; resulting in morphine overdose
What effect will UM have on prodrugs like codeine?
decreased efficacy; won't be converted to morphine
What effect will PM have on prodrug like codeine?
SSRI or SNRI
What are the gold standard treatments for major depressive disorder?
Serotonin MOA
block serotonin reuptake via SLC6A4 transporter; preventing reuptake into presynaptic neurons
active
All SSRI are ________ parent drugs.
CYP2D6, CYP2C19
Patients may be predisposed to poor therapeutic outcomes when taking SSRIs due to ________ or __________ polymorphisms.
CYP2D6
Paroxetine is metabolized which enzyme?
select alternative drug not metabolized by CYP2D6
What is the therapeutic recommendation for a UM in regards to Paroxetine & Atomoxetine ?
lower starting dose by 50% or select different drug
What is the therapeutic recommendation for a PM in regards to Paroxetine & Atomoxetine?
SSRI
What is pharmacological class of Paroxetine?
SNRI
What is the pharmacological class of Atomoxetine (Strattera)?
CYP2C19*2; CYP2C19*3
What is the nomenclature for inactive CYP2C19 enzymes?
CYP2C19*17
What is the nomenclature for increased function CYP2C19 enzymes?
ultrarapid metabolizer
What is the phenotype of someone who has *1/*17?
poor metabolizer
What is the phenotype of someone who has *2/*3?
Escitalopram (LEXAPRO)
- is the S-enantiomer
-an active compound
- metabolized by CYP2C19
OCD, chronic pain, migraine prophylaxis
Tricyclic Antidepressants are used to treat depression but are also used for_______
serotonin system
"3" or tertiary amine side chain has a greater impact on the _______
norepinephrine system
"2" or secondary amine side chain has a greater impact on the ______
B; lacks an alkyl group
A refers to the drug on the left; B refers to the drug on the right.
Which one is norepinephrine? How do you know?
serotonin system; tertiary amine
This drug will exert its best effect on _______. How do you know this?
norepinephrine system; secondary amine
This drug will exert its best effect on _______. How do you know this?
Phenoconversion
-genetically mediated metabolic activity is converted to a different metabolic activity phenotype due to an intrinsic factor; usually from drug-drug interactions
Risk evaluation mitigation strategy; clozapine
Patients and providers must be registered in the __________ when _________ is prescribed.
pseudo-parkinsons; blocking too much
1st gen or typical antipsychotics can cause __________ from __________ dopamine.
d
Clozapine reduces what type of leukocyte?
a. eosinophils
b. macrophages
c. basophils
d. neutrophils
CYP1A2
Clozapine is primarily metabolized by _____
Patients with A/A may require larger dose
A single nucleotide polymorphism of CYP1A2 suggests that the A/A genotype was more inducible than the C/A or C/C genotypes. What does this mean for prescribers?
CYP2B6
What is the enzyme responsible for metabolizing Buproprion?