Hosam Mohamed-
inhibit bacterial DNA replication by inhibiting DNA gyrase & topoisomerase IV
What is the MOA for Fluroquinolones?
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increased risk of tendinitis & tendon rupture; especially older patients
What is the BBW for Fluroquinolones?
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myasthenia gravis
Fluroquinolones are CI in patients with what condition?
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cartilage toxicity, joint sweling, mitochondria ROS, decreased magnesium, degraded collagen, headache, fatigue
What are SE's associated with Fluroquinolones?
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psychosis, hallucinations, depression, seizures
Rare SE's of Fluoroquinolone use?
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alter: DNA gyrase, membrane proteins
How do Gm (-) bacteria resist Fluoroquinolones?
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alter DNA gyrase and topoisomerase
How do Gm(+) bacteria resist Fluroquinolones?
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vitamins, minerals, dairy; chelation reaction
What foods do we avoid with Fluoroquinolone use? Why?
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antiarrhythmics, bp meds, macrolides
What drugs do we avoid with Fluoroquinolones?
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b
Concomitant Fluoroquinolone & CNS agent use can cause what ?
a) CNS side effcts
b) increased QT times
c) increased Prothrombin times
d) chelation
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a
Concomitant Fluoroquinolone & NSAID use can cause what?
a) CNS side effcts
b) increased QT times
c) increased Prothrombin times
d) chelation
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c
Concomitant Fluoroquinolone & Warfarin use can cause what ?
a) CNS side effcts
b) increased QT times
c) increased Prothrombin times
d) chelation
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UTI, pneumonia, chlamydia, chancroid
What infections can we treat with FQ's?
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moxifloxacin
What FQ is the only one active against anaerobes?
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strep, MSSA
What gm (+) bacteria can we treat with FQ's?
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entero, e.coli, h.flu, salmonella, shigella, legionella, chlamydia, pseudomonas
What gm (-) bacteria ca we treat with FQ's?
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mycoplasma
FQ's are also active against ________ bacteria
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pregnant women and persons under the age of 18
Who should we avoid using FQ's in?
