inhibit bacterial DNA replication by inhibiting DNA gyrase & topoisomerase IV
What is the MOA for Fluroquinolones?
increased risk of tendinitis & tendon rupture; especially older patients
What is the BBW for Fluroquinolones?
myasthenia gravis
Fluroquinolones are CI in patients with what condition?
cartilage toxicity, joint sweling, mitochondria ROS, decreased magnesium, degraded collagen, headache, fatigue
What are SE's associated with Fluroquinolones?
psychosis, hallucinations, depression, seizures
Rare SE's of Fluoroquinolone use?
alter: DNA gyrase, membrane proteins
How do Gm (-) bacteria resist Fluoroquinolones?
alter DNA gyrase and topoisomerase
How do Gm(+) bacteria resist Fluroquinolones?
vitamins, minerals, dairy; chelation reaction
What foods do we avoid with Fluoroquinolone use? Why?
antiarrhythmics, bp meds, macrolides
What drugs do we avoid with Fluoroquinolones?
b
Concomitant Fluoroquinolone & CNS agent use can cause what ?
a) CNS side effcts
b) increased QT times
c) increased Prothrombin times
d) chelation
a
Concomitant Fluoroquinolone & NSAID use can cause what?
a) CNS side effcts
b) increased QT times
c) increased Prothrombin times
d) chelation
c
Concomitant Fluoroquinolone & Warfarin use can cause what ?
a) CNS side effcts
b) increased QT times
c) increased Prothrombin times
d) chelation
UTI, pneumonia, chlamydia, chancroid
What infections can we treat with FQ's?
moxifloxacin
What FQ is the only one active against anaerobes?
strep, MSSA
What gm (+) bacteria can we treat with FQ's?
entero, e.coli, h.flu, salmonella, shigella, legionella, chlamydia, pseudomonas
What gm (-) bacteria ca we treat with FQ's?
mycoplasma
FQ's are also active against ________ bacteria
pregnant women and persons under the age of 18
Who should we avoid using FQ's in?