Hosam Mohamed-
nalidixic acid, ciprofloxacin, ofloxacin, levofloxacin
What are our first generation fluoroquinolones?
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Gatifloxacin
What are our second generation fluroquinolones?
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moxifloxacin, gemifloxacin, finafloxacin, delafloxacin
What are our 3rd generation fluoroquinolones?
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Ozenoxacin
What is our New Quinolone?
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b
Which 1st generation FQ has limited UTI effect and is NOT used in the U.S. ?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
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c,d
Which 1st generation FQ has a methylpiperazine group?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
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c
Which 1st generation FQ is a racemic mixture?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
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d
Which 1st generation FQ has a single chiral form?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
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a
Which 1st gen FQ has a drug interaction with xanthines ?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
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pseudomonas, legionella, mycoplasma, anthrax
Ciprofloxacin is 1st line for :
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d
Which 1st gen FQ has an increased potency and reduced SE's?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
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c
Which 1st gen FQ is used as drops for eye & ear infections?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
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d
Which 1st gen FQ is used 1st line for pen-resistant strep?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
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eye infections; increased activity against GM + and anaerobes
Gatifloxacin tx & spectrum?
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d
Gatifloxacin comes in what form?
a) oral
b) iv
c) cream
d) drops
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Omethyl and cyclopropyl
Gatifloxacin possess what chemical additions?
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a,c
Which 3rd gen FQ is good for Gm + & Gm - anaerobes?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
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a,c
Which 3rd gen FQ is 1st line for pen-resistant strep?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
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a
Which 3rd gen FQ has the best activity against strep & anaerobes?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
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b
Which 3rd gen FQ is used to treat swimmer's ear?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
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d
Which 3rd gen FQ can be used to treat skin infections and MRSA?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
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a
Which 3rd gen FQ has SE's of rash ( especially in women) ?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
-
b
Which 3rd gen FQ possess a CYANO group that increases its activity against CA-MRSA?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
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impetigo, MRSA, strep; topical cream
What is the tx of Ozenoxacin? How is it administered?
