nalidixic acid, ciprofloxacin, ofloxacin, levofloxacin
What are our first generation fluoroquinolones?
Gatifloxacin
What are our second generation fluroquinolones?
moxifloxacin, gemifloxacin, finafloxacin, delafloxacin
What are our 3rd generation fluoroquinolones?
Ozenoxacin
What is our New Quinolone?
b
Which 1st generation FQ has limited UTI effect and is NOT used in the U.S. ?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
c,d
Which 1st generation FQ has a methylpiperazine group?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
c
Which 1st generation FQ is a racemic mixture?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
d
Which 1st generation FQ has a single chiral form?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
a
Which 1st gen FQ has a drug interaction with xanthines ?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
pseudomonas, legionella, mycoplasma, anthrax
Ciprofloxacin is 1st line for :
d
Which 1st gen FQ has an increased potency and reduced SE's?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
c
Which 1st gen FQ is used as drops for eye & ear infections?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
d
Which 1st gen FQ is used 1st line for pen-resistant strep?
a) ciprofloxacin
b) nalidixic acid
c) ofloxacin
d) levofloxacin
eye infections; increased activity against GM + and anaerobes
Gatifloxacin tx & spectrum?
d
Gatifloxacin comes in what form?
a) oral
b) iv
c) cream
d) drops
Omethyl and cyclopropyl
Gatifloxacin possess what chemical additions?
a,c
Which 3rd gen FQ is good for Gm + & Gm - anaerobes?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
a,c
Which 3rd gen FQ is 1st line for pen-resistant strep?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
a
Which 3rd gen FQ has the best activity against strep & anaerobes?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
b
Which 3rd gen FQ is used to treat swimmer's ear?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
d
Which 3rd gen FQ can be used to treat skin infections and MRSA?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
a
Which 3rd gen FQ has SE's of rash ( especially in women) ?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
b
Which 3rd gen FQ possess a CYANO group that increases its activity against CA-MRSA?
a) Gemifloxacin
b) finafloxacin
c) moxifloxacin
d) delafloxacin
impetigo, MRSA, strep; topical cream
What is the tx of Ozenoxacin? How is it administered?