2023-09-19T00:52:50+03:00[Europe/Moscow] en true <p>0.7</p>, <p>1</p>, <p>two-compartment </p>, <p>f; distributes a lot into skeletal muscle </p>, <p>central compartment doesn't include myocardium; delayed onset of action</p>, <p>6-8 hrs</p>, <p>36 hrs</p>, <p>b</p>, <p>albumin; 20-25</p>, <p>&gt; 12 hrs</p>, <p>40 ml/min</p>, <p>20 ml/min</p> flashcards
Digoxin PK

Digoxin PK

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  • 0.7

    What is the bioavailability of Digoxin tablets?

  • 1

    What is the bioavailability of Digoxin IV?

  • two-compartment

    What kind of distribution does Digoxin exhibit?

  • f; distributes a lot into skeletal muscle

    Digoxin distributes well into fat. T/F?

  • central compartment doesn't include myocardium; delayed onset of action

    Why are serum samples useless during the distribution phase?

  • 6-8 hrs

    What's the minimum amount of time to collect serum samples?

  • 36 hrs

    How long is Digoxin's Half-life?

  • b

    What is the most important pharmacokinetic parameter with Digoxin?

    a) Volume of Distribution

    b) Clearance

    c) F

    d) Steady State

  • albumin; 20-25

    Digoxin binds to ______ at about _______ percent.

  • > 12 hrs

    When is the best time to collect Digoxin samples?

  • 40 ml/min

    What is the CL is a patient has no/ mild HF?

  • 20 ml/min

    What is the CL if a patient has moderate to severe heart failure

    (NYHA Class III or IV) ?